ArticleInfection and immunity2001
Nitric oxide is protective in listeric meningoencephalitis of rats.
Article in Infection and immunity, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
14 citing papers in PubMed, 30 citations in OpenAlex.
- Pathogenic Differences of Type 1 Restriction-Modification Allele Variants in ExperimentalFrontiers in cellular and infection microbiology · 2020Article
- Short-term consumption of a high-fat diet increases host susceptibility to Listeria monocytogenes infection.Microbiome · 2019Article
- Characterization of a Listeria monocytogenes meningitis mouse model.Journal of neuroinflammation · 2018Article
- c-Src kinase is involved in the tyrosine phosphorylation and activity of SLC11A1 in differentiating macrophages.PloS one · 2018Article
- Nitric oxide and redox mechanisms in the immune response.Journal of leukocyte biology · 2011Review
- The behaviour of both Listeria monocytogenes and rat ciliated ependymal cells is altered during their co-culture.PloS one · 2010Article
- Bioluminescence imaging of reporter mice for studies of infection and inflammation.Antiviral research · 2010Review
- Nitric oxide/cGMP signalling induces Escherichia coli K1 receptor expression and modulates the permeability in human brain endothelial cell monolayers during invasion.Cellular microbiology · 2010Article
- Beta-naphthoflavone causes an AhR-independent inhibition of invasion and intracellular multiplication of Listeria monocytogenes in murine hepatocytes.Microbial pathogenesis · 2009Article
- Rapid diagnosis of experimental meningitis by bacterial heat production in cerebrospinal fluid.BMC infectious diseases · 2007Article
- Interleukin-1 receptor type 1 is essential for control of cerebral but not systemic listeriosis.The American journal of pathology · 2007Article
- PCR-based diagnosis of Naegleria sp. infection in formalin-fixed and paraffin-embedded brain sections.Journal of clinical microbiology · 2007Article
- Evidence for involvement of peptidoglycan in the triggering of an oxidative burst by Listeria monocytogenes in phagocytes.Clinical and experimental immunology · 2005Article
- Measurements in vivo of parameters pertinent to ROS/RNS using EPR spectroscopy.Molecular and cellular biochemistryReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
Abstract
The bacterium Listeria monocytogenes causes meningoencephalitis in humans. In rodents, listeriosis is associated with granulomatous lesions in the liver and the spleen, but not with meningoencephalitis. Here, infant rats were infected intracisternally to generate experimental listeric meningoencephalitis. Dose-dependent effects of intracisternal inoculation with L. monocytogenes on survival and activity were noted; 10(4) L. monocytogenes organisms induced a self-limiting brain infection. Bacteria invaded the basal meninges, chorioid plexus and ependyme, spread to subependymal tissue and hippocampus, and disappeared by day 7. This was paralleled by recruitment and subsequent disappearance of macrophages expressing inducible nitric oxide synthase (iNOS) and nitrotyrosine accumulation, an indication of nitric oxide (NO.) production. Treatment with the spin-trapping agent alpha-phenyl-tert-butyl nitrone (PBN) dramatically increased mortality and led to bacterial numbers in the brain 2 orders of magnitude higher than in control animals. Treatment with the selective iNOS inhibitor L-N(6)-(1-iminoethyl)-lysine (L-NIL) increased mortality to a similar extent and led to 1 order of magnitude higher bacterial counts in the brain, compared with controls. The numbers of bacteria that spread to the spleen and liver did not significantly differ among L-NIL-treated, PBN-treated, and control animals. Thus, the infant rat brain is able to mobilize powerful antilisterial mechanisms, and both reactive oxygen and NO. contribute to Listeria growth control.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.