ArticleInfection and immunity2001
Analysis of mechanisms associated with loss of infectivity of clonal populations of Borrelia burgdorferi B31MI.
Article in Infection and immunity, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
36 citing papers in PubMed, 54 citations in OpenAlex.
- Deletion of a Genetic Region of lp17 Affects Plasmid Copy Number inFrontiers in cellular and infection microbiology · 2022Article
- Diversity of the Lyme Disease Spirochetes and its Influence on Immune Responses to Infection and Vaccination.The Veterinary clinics of North America. Small animal practice · 2019Review
- Assessment of the potential contribution of the highly conserved C-terminal motif (C10) of Borrelia burgdorferi outer surface protein C in transmission and infectivity.Pathogens and disease · 2014Article
- Identification of Borrelia burgdorferi ospC genotypes in canine tissue following tick infestation: implications for Lyme disease vaccine and diagnostic assay design.Veterinary journal (London, England : 1997) · 2013Article
- Complement regulator-acquiring surface proteins of Borrelia burgdorferi: Structure, function and regulation of gene expression.Ticks and tick-borne diseases · 2013Review
- The role of Borrelia burgdorferi outer surface proteins.FEMS immunology and medical microbiology · 2012Review
- The diguanylate cyclase, Rrp1, regulates critical steps in the enzootic cycle of the Lyme disease spirochetes.Molecular microbiology · 2011Article
- Genetic transformation of the relapsing fever spirochete Borrelia hermsii: stable integration and expression of green fluorescent protein from linear plasmid 200.Journal of bacteriology · 2011Article
- Inactivation of bb0184, which encodes carbon storage regulator A, represses the infectivity of Borrelia burgdorferi.Infection and immunity · 2011Article
- Role of acetyl-phosphate in activation of the Rrp2-RpoN-RpoS pathway in Borrelia burgdorferi.PLoS pathogens · 2010Article
- Role of the surface lipoprotein BBA07 in the enzootic cycle of Borrelia burgdorferi.Infection and immunity · 2010Article
- Identification of residues within ligand-binding domain 1 (LBD1) of the Borrelia burgdorferi OspC protein required for function in the mammalian environment.Molecular microbiology · 2010Article
- Borrelia burgdorferi locus BB0795 encodes a BamA orthologue required for growth and efficient localization of outer membrane proteins.Molecular microbiology · 2010Article
- Characterization of the highly regulated antigen BBA05 in the enzootic cycle of Borrelia burgdorferi.Infection and immunity · 2010Article
- CspA-mediated binding of human factor H inhibits complement deposition and confers serum resistance in Borrelia burgdorferi.Infection and immunity · 2009Article
- Rrp1, a cyclic-di-GMP-producing response regulator, is an important regulator of Borrelia burgdorferi core cellular functions.Molecular microbiology · 2009Article
- Borrelia burgdorferi complement regulator-acquiring surface protein 2 does not contribute to complement resistance or host infectivity.PloS one · 2008Article
- Persistence of Borrelia burgdorferi following antibiotic treatment in mice.Antimicrobial agents and chemotherapy · 2008Article
- Role of the BBA64 locus of Borrelia burgdorferi in early stages of infectivity in a murine model of Lyme disease.Infection and immunity · 2008Article
- Delineation of species-specific binding properties of the CspZ protein (BBH06) of Lyme disease spirochetes: evidence for new contributions to the pathogenesis of Borrelia spp.Infection and immunity · 2007Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Numerous studies have provided suggestive evidence that the loss of plasmids correlates with the loss of infectivity of the Lyme disease spirochetes. In this study we have further investigated this correlation. Clonal populations were obtained from the skin of a mouse infected for 3 months with a clonal population of Borrelia burgdorferi B31MI. The complete plasmid compositions of these populations were determined using a combination of PCR and Southern hybridization. The infectivities of clones differing in plasmid composition were tested using the C3H-HeJ murine model for Lyme disease. While several clones were found to be noninfectious, a correlation between the loss of a specific plasmid and loss of infectivity in the clones analyzed in this report was not observed. While it is clear from recent studies that the loss of some specific plasmids results in attenuated virulence, this study demonstrates that additional mechanisms also contribute to the loss of infectivity.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.