ArticleInfection and immunity2001
Differential induction of gamma interferon in Legionella pneumophila-infected macrophages from BALB/c and A/J mice.
Article in Infection and immunity, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
12 citing papers in PubMed, 43 citations in OpenAlex.
- CXCL1 augments host defense against Legionella pneumophila through the IL-18-IFN-γ axis and neutrophil homeostasis.Journal of immunology (Baltimore, Md. : 1950) · 2025Article
- Enhancement of mycobacterial pathogenesis by host interferon-γ.Cellular and molecular life sciences : CMLS · 2024Article
- Concept about the Virulence Factor ofMicroorganisms · 2022Review
- Hemojuvelin regulates the innate immune response to peritoneal bacterial infection in mice.Cell discovery · 2017Article
- Complete and ubiquitinated proteome of the Legionella-containing vacuole within human macrophages.Journal of proteome research · 2015Article
- The role of interferon-γ in the pathogenesis of acute intra-abdominal sepsis.Journal of leukocyte biology · 2010Article
- Cytokines involved in interferon-gamma production by human macrophages.Journal of innate immunity · 2010Article
- Role of endogenous IFN-gamma in macrophage programming induced by IL-12 and IL-18.Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research · 2007Article
- Role of Toll-like receptor 9 in Legionella pneumophila-induced interleukin-12 p40 production in bone marrow-derived dendritic cells and macrophages from permissive and nonpermissive mice.Infection and immunity · 2007Article
- Legionella pneumophila evades gamma interferon-mediated growth suppression through interleukin-10 induction in bone marrow-derived macrophages.Infection and immunity · 2005Article
- Differential roles of Toll-like receptors 2 and 4 in in vitro responses of macrophages to Legionella pneumophila.Infection and immunity · 2005Article
- Macrophages from mice with the restrictive Lgn1 allele exhibit multifactorial resistance to Legionella pneumophila.Infection and immunity · 2004Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Gamma interferon (IFN-gamma), a pleiotropic cytokine, is now known to be produced by macrophages as well as by NK cells, gammadelta cells, and activated T cells. The autocrine biological functions of IFN-gamma on the macrophage include the upregulation of major histocompatibility complex MHC class II and the activation to an antiviral state. In this study, the production of IFN-gamma by macrophages was demonstrated to correspond to antibacterial activity. Legionella pneumophila replicates intracellularly in thioglycolate (TG)-elicited macrophages (TG-macrophages) from A/J mice, while TG-macrophages from BALB/c mice restrict bacterial growth after an initial period of growth. BALB/c TG-macrophages were shown to express IFN-gamma mRNA at 24 and 28 h, which corresponded to the initiation of anti-L. pneumophila activity. Moreover, IFN-gammaneutralization by antibody treatment of the cultures resulted in increased L. pneumophila growth in the macrophages. In contrast, no IFN-gamma mRNA was expressed in TG-macrophages from A/J mice, where L. pneumophila grew unrestricted. As would be expected, IFN-gamma treatment decreased bacterial growth. An IFN-gamma-mediated antibacterial activity was, however, inducible in A/J macrophages by the addition of interleukin-12 following L. pneumophila infection. Thus, autocrine IFN-gamma is involved in anti-L. pneumophila activity associated with different growth patterns and appears to be important during intracellular infection.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.