ArticleCell proliferation2001
Pattern of self-organization in tumour systems: complex growth dynamics in a novel brain tumour spheroid model.
Article in Cell proliferation, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 68 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
68 citing papers in PubMed.
- Spheroid Invasion Assay of Melanoma Cells by Hanging Drop Technique.Methods in molecular biology (Clifton, N.J.) · 2027Article
- Insights from a multiscale framework on metabolic rate variation driving glioblastoma multiforme growth and invasion.Communications engineering · 2024Article
- Fractal dimension: analyzing its potential as a neuroimaging biomarker for brain tumor diagnosis using machine learning.Frontiers in physiology · 2023Article
- In Silico Mathematical Modelling for Glioblastoma: A Critical Review and a Patient-Specific Case.Journal of clinical medicine · 2021Review
- Challenges of applying multicellular tumor spheroids in preclinical phase.Cancer cell international · 2021Review
- Navigating Multi-Scale Cancer Systems Biology Towards Model-Driven Clinical Oncology and Its Applications in Personalized Therapeutics.Frontiers in oncology · 2021Review
- 3D Tumor Spheroid Models for In Vitro Therapeutic Screening of Nanoparticles.Advances in experimental medicine and biology · 2021Article
- Is the Fixed Periodic Treatment Effective for the Tumor System without Complete Information?Cancer management and research · 2021Article
- Head-to-Head Comparison of the Penetration Efficiency of Lipid-Based Nanoparticles into Tumor Spheroids.ACS omega · 2020Article
- Self-organization in brain tumors: How cell morphology and cell density influence glioma pattern formation.PLoS computational biology · 2020Article
- A three-dimensional (3D) organotypic microfluidic model for glioma stem cells - Vascular interactions.Biomaterials · 2019Article
- The mechanical and pharmacological regulation of glioblastoma cell migration in 3D matrices.Journal of cellular physiology · 2019Article
- Integrating in vitro experiments with in silico approaches for Glioblastoma invasion: the role of cell-to-cell adhesion heterogeneity.Scientific reports · 2018Article
- Embedded Spheroids as Models of the Cancer Microenvironment.Advanced biosystems · 2017Article
- Dynamics of cancerous tissue correlates with invasiveness.Scientific reports · 2017Article
- Identifying the necrotic zone boundary in tumour spheroids with pair-correlation functions.Journal of the Royal Society, Interface · 2016Article
- Tumor proliferation and diffusion on percolation clusters.Journal of biological physics · 2016Article
- Impact of multicellular tumor spheroids as an in vivo‑like tumor model on anticancer drug response.International journal of oncology · 2016Article
- Anti-gastric cancer activity in three-dimensional tumor spheroids of bufadienolides.Scientific reports · 2016Article
- Three-dimensional microtissues essentially contribute to preclinical validations of therapeutic targets in breast cancer.Cancer medicine · 2016Article
8 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
We propose that a highly malignant brain tumour is an opportunistic, self-organizing and adaptive complex dynamic biosystem rather than an unorganized cell mass. To test the hypothesis of related key behaviour such as cell proliferation and invasion, we have developed a new in vitro assay capable of displaying several of the dynamic features of this multiparameter system in the same experimental setting. This assay investigates the development of multicellular U87MGmEGFR spheroids in a specific extracellular matrix gel over time. The results show that key features such as volumetric growth and cell invasion can be analysed in the same setting over 144 h without continuously supplementing additional nutrition. Moreover, tumour proliferation and invasion are closely correlated and both key features establish a distinct ratio over time to achieve maximum cell velocity and to maintain the system's temporo-spatial expansion dynamics. Single cell invasion follows a chain-like pattern leading to the new concept of a intrabranch homotype attraction. Since preliminary studies demonstrate that heterotype attraction can specifically direct and accelerate the emerging invasive network, we further introduce the concept of least resistance, most permission and highest attraction as an essential principle for tumour invasion. Together, these results support the hypothesis of a self-organizing adaptive biosystem.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.