ArticleBMC developmental biology2001
Calcium dynamics during fertilization in C. elegans.
Article in BMC developmental biology, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 61 citations in OpenAlex.
- Programmed mitophagy at the oocyte-to-zygote transition promotes lineage endurance.Nature cell biology · 2026Article
- In Vivo Visualization of Calcium Transients during Fertilization and Early Development in C. elegans.Journal of visualized experiments : JoVE · 2024Article
- Visualization of the biphasic calcium wave during fertilization in Caenorhabditis elegans using a genetically encoded calcium indicator.Biology open · 2023Article
- CRISPR/Cas9 Mediated Fluorescent Tagging ofBiomolecules · 2023Article
- Sperm-Guiding Unconventional Prostaglandins inMetabolites · 2021Review
- Statistical image processing quantifies the changes in cytoplasmic texture associated with aging in Caenorhabditis elegans oocytes.BMC bioinformatics · 2021Article
- Cytoplasmic streaming drifts the polarity cue and enables posteriorization of theMolecular biology of the cell · 2020Article
- Fndc-1 contributes to paternal mitochondria elimination in C. elegans.Developmental biology · 2019Article
- H3.3K27M-induced chromatin changes drive ectopic replication through misregulation of the JNK pathway in C. elegans.Nature communications · 2019Article
- Control of oocyte meiotic maturation in C. elegans.Seminars in cell & developmental biology · 2018Review
- The C. elegans eggshell.WormBook : the online review of C. elegans biology · 2018Review
- Article
- Maternal MEMI Promotes Female Meiosis II in Response to Fertilization in Caenorhabditis elegans.Genetics · 2016Article
- Control of oocyte growth and meiotic maturation in Caenorhabditis elegans.Advances in experimental medicine and biology · 2013Review
- Molecular changes during egg activation.Current topics in developmental biology · 2013Review
- Calcium signaling surrounding fertilization in the nematode Caenorhabditis elegans.Cell calcium · 2013Review
- Kinesin-1 prevents capture of the oocyte meiotic spindle by the sperm aster.Developmental cell · 2012Article
- Macro-level modeling of the response of C. elegans reproduction to chronic heat stress.PLoS computational biology · 2012Article
- Time-lapse microscopy of early embryogenesis in Caenorhabditis elegans.Journal of visualized experiments : JoVE · 2011Article
- The genetics and cell biology of fertilization.Methods in cell biology · 2011Review
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundOf the animals typically used to study fertilization-induced calcium dynamics, none is as accessible to genetics and molecular biology as the model organism Caenorhabditis elegans. Motivated by the experimental possibilities inherent in using such a well-established model organism, we have characterized fertilization-induced calcium dynamics in C. elegans.
resultsOwing to the transparency of the nematode, we have been able to study the calcium signal in C. elegans fertilization in vivo by monitoring the fluorescence of calcium indicator dyes that we introduce into the cytosol of oocytes. In C. elegans, fertilization induces a single calcium transient that is initiated soon after oocyte entry into the spermatheca, the compartment that contains sperm. Therefore, it is likely that the calcium transient is initiated by contact with sperm. This calcium elevation spreads throughout the oocyte, and decays monotonically after which the cytosolic calcium concentration returns to that preceding fertilization. Only this single calcium transient is observed.
conclusionDevelopment of a technique to study fertilization induced calcium transients opens several experimental possibilities, e.g., identification of the signaling events intervening sperm binding and calcium elevation, identifying the possible roles of the calcium elevation such as the completion of meiosis, the formation of the eggshell, and the establishing of the embryo's axis of symmetry.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.