ArticleProceedings of the National Academy of Sciences of the United States of America2001
Vascular patterning defects associated with expression of activated Notch4 in embryonic endothelium.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 104 papers.
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Who cites it
104 citing papers in PubMed, 287 citations in OpenAlex.
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- Inhibition of endothelial histone deacetylase 2 shifts endothelial-mesenchymal transitions in cerebral arteriovenous malformation models.The Journal of clinical investigation · 2024Article
- PI(4,5)PScience advances · 2023Article
- Neurodevelopmental and genetic findings in neonates with intracranial arteriovenous shunts: A case series.Frontiers in pediatrics · 2023Article
- Inactivation ofCancer research communications · 2022Article
- The Beauty and Complexity of Blood Vessel Patterning.Cold Spring Harbor perspectives in medicine · 2022Review
- Endothelial Cell Fate Determination: A Top Notch Job in Vascular Decision-Making.Cold Spring Harbor perspectives in medicine · 2022Review
- Preliminary Research of Main Components of Dll4/ Notch-VEGF Signaling Pathway Under High-Glucose Stimulation in vitro.Diabetes, metabolic syndrome and obesity : targets and therapy · 2022Article
- Effect of the Notch4/Dll4 signaling pathway in early gestational intrauterine infection on lung development.Experimental and therapeutic medicine · 2021Article
- Biological potentials for a family of disintegrin and metalloproteinase (ADAMDEC)-1 in mouse normal pregnancy.The Journal of veterinary medical science · 2021Article
- NOTCH signalling in ovarian cancer angiogenesis.Annals of translational medicine · 2020Review
- Methylation status of CpG sites in the NOTCH4 promoter region regulates NOTCH4 expression in patients with tetralogy of Fallot.Molecular medicine reports · 2020Article
- Myoendothelial Junctions of Mature Coronary Vessels Express Notch Signaling Proteins.Frontiers in physiology · 2020Article
- Biomarkers of Activation and Inflammation to Track Disparity in Chronological and Physiological Age of People Living With HIV on Combination Antiretroviral Therapy.Frontiers in immunology · 2020Review
- Article
- Elevated endothelial Sox2 causes lumen disruption and cerebral arteriovenous malformations.The Journal of clinical investigation · 2019Article
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- The Use of Nutraceuticals to Counteract Atherosclerosis: The Role of the Notch Pathway.Oxidative medicine and cellular longevity · 2019Review
- Notch signaling pathway is a potential therapeutic target for extracranial vascular malformations.Scientific reports · 2018Article
44 more citing papers are in PubMed but not listed here.
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
Abstract
Notch proteins function as receptors for membrane-bound ligands (Jagged and Delta-like) to regulate cell-fate determination. We have investigated the role of Notch signaling in embryonic endothelium of the mouse by expressing an activated form of the Notch4 protein in vasculature under the regulation of the Flk1 (VEGFR) locus. Expression of activated Notch4 results in a growth and developmental delay and embryonic lethality at about 10 days postcoitum. The extent of the developing vasculature in mutant embryos was restricted, fewer small vessels were seen, and vascular networks were disorganized. The brain periphery of mutant embryos contained large dilated vessels with evidence of compromised vessel-wall integrity and large areas of necrosis; yolk-sac vasculature was abnormal. Expression of an activated form of Notch4 in embryonic vasculature leads to abnormal vessel structure and patterning, implicating the Notch pathway in phases of vascular development associated with vessel patterning and remodeling.
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