ArticleThe Journal of experimental medicine2001
The Exocytosis-regulatory protein synaptotagmin VII mediates cell invasion by Trypanosoma cruzi.
Article in The Journal of experimental medicine, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
23 citing papers in PubMed, 75 citations in OpenAlex.
- Article
- Lysosome function in glomerular health and disease.Cell and tissue research · 2021Review
- Mechanisms Associated withLife (Basel, Switzerland) · 2021Review
- Cellular mechanisms and signals that coordinate plasma membrane repair.Cellular and molecular life sciences : CMLS · 2018Review
- The Dialogue of the Host-Parasite Relationship: Leishmania spp. and Trypanosoma cruzi Infection.BioMed research international · 2015Review
- Mechanisms of cellular invasion by intracellular parasites.Cellular and molecular life sciences : CMLS · 2014Review
- Trans-sialidase stimulates eat me response from epithelial cells.Traffic (Copenhagen, Denmark) · 2013Article
- Active penetration of Trypanosoma cruzi into host cells: historical considerations and current concepts.Frontiers in immunology · 2013Article
- Membrane traffic and synaptic cross-talk during host cell entry by Trypanosoma cruzi.Cellular microbiology · 2012Article
- Molecular and cellular mechanisms involved in the Trypanosoma cruzi/host cell interplay.IUBMB life · 2012Review
- Host cell invasion by Trypanosoma cruzi: a unique strategy that promotes persistence.FEMS microbiology reviews · 2012Review
- Invasion and intracellular survival by protozoan parasites.Immunological reviews · 2011Review
- Molecular mechanisms of host cell invasion by Trypanosoma cruzi.Experimental parasitology · 2010Review
- Palmitoylation-dependent association with CD63 targets the Ca2+ sensor synaptotagmin VII to lysosomes.The Journal of cell biology · 2010Article
- Molecular analysis of early host cell infection by Trypanosoma cruzi.Frontiers in bioscience : a journal and virtual library · 2008Review
- Expression and function of synaptotagmin VII in CTLs.Journal of immunology (Baltimore, Md. : 1950) · 2007Article
- Ca2+ and synaptotagmin VII-dependent delivery of lysosomal membrane to nascent phagosomes.The Journal of cell biology · 2006Article
- A role for synaptotagmin VII-regulated exocytosis of lysosomes in neurite outgrowth from primary sympathetic neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2006Article
- Cytolysin-dependent evasion of lysosomal killing.Proceedings of the National Academy of Sciences of the United States of America · 2005Article
- A new cruzipain-mediated pathway of human cell invasion by Trypanosoma cruzi requires trypomastigote membranes.Infection and immunity · 2004Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
The intracellular protozoan parasite Trypanosoma cruzi causes Chagas' disease, which affects millions of people in Latin America. T. cruzi enters a large number of cell types by an unusual mechanism that involves Ca(2+)-triggered fusion of lysosomes with the plasma membrane. Here we show that synaptotagmin VII (Syt VII), a ubiquitously expressed synaptotagmin isoform that regulates exocytosis of lysosomes, is localized on the membranes of intracellular vacuoles containing T. cruzi. Antibodies against the C(2)A domain of Syt VII or recombinant peptides including this domain inhibit cell entry by T. cruzi, but not by Toxoplasma gondii or Salmonella typhimurium. The C(2)A domains of other ubiquitously expressed synaptotagmin isoforms have no effect on T. cruzi invasion, and mutation of critical residues on Syt VII C(2)A abolish its inhibitory activity. These findings indicate that T. cruzi exploits the Syt VII-dependent, Ca(2+)-regulated lysosomal exocytic pathway for invading host cells.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.