ArticleThe Plant cell2001
Mitochondrial aldehyde dehydrogenase activity is required for male fertility in maize.
Article in The Plant cell, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 97 papers.
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Who cites it
97 citing papers in PubMed, 253 citations in OpenAlex.
- Non-functional allele ofPlant biotechnology (Tokyo, Japan) · 2026Article
- Exploring Transcriptomic Microsatellite Markers inEcology and evolution · 2026Article
- Genetic mapping of fertility restoration (Rf) genes and development-validation of linked SNPs for AJournal of applied genetics · 2026Article
- Multiple fertility restorer loci for cytoplasmic male sterility caused by mitochondrial gene orf137 in tomato.Journal of experimental botany · 2025Article
- Temperature-dependent benefits and costs of cytoplasmic male sterility in snailProceedings. Biological sciences · 2025Article
- Genome-Wide Identification and Expression Analysis of the Melon Aldehyde Dehydrogenase (ALDH) Gene Family in Response to Abiotic and Biotic Stresses.Plants (Basel, Switzerland) · 2024Article
- Review
- Insights into cellular crosstalk regulating cytoplasmic male sterility and fertility restoration.Molecular biology reports · 2024Review
- A P-type pentatricopeptide repeat protein ZmRF5 promotes 5' region partial cleavages of atp6c transcripts to restore the fertility of CMS-C maize by recruiting a splicing factor.Plant biotechnology journal · 2024Article
- Deciphering Physio-Biochemical Basis of Tolerance Mechanism for Sesame (Plants (Basel, Switzerland) · 2024Article
- Fine mapping and candidate gene analysis of a novel fertility restorer gene for C-type cytoplasmic male sterility in maize (Zea mays L.).TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2023Article
- Male sterility in plants: an overview of advancements from natural CMS to genetically manipulated systems for hybrid seed production.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2023Review
- Molecular genetics of cytoplasmic male sterility and restorer-of-fertility for the fine tuning of pollen production in crops.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2023Review
- Identification of fertility restoration candidate genes from a restorer line R186 for Gossypium harknessii cytoplasmic male sterile cotton.BMC plant biology · 2023Article
- Fujian cytoplasmic male sterility and the fertility restorer geneProceedings of the National Academy of Sciences of the United States of America · 2022Article
- Tissue-specific transcriptomics reveal functional differences in floral development.Plant physiology · 2022Article
- RNA-seq analysis reveals genes related to photosynthetic carbon partitioning and lipid production inFrontiers in microbiology · 2022Article
- Identification ofInternational journal of molecular sciences · 2021Article
- Genetic mapping reveals BjRf as a candidate gene controlling fertility restoration of the oxa CMS in Brassica juncea.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2021Article
- Identification and validation of genetic locus Rfk1 for wheat fertility restoration in the presence of Aegilops kotschyi cytoplasm.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2021Article
37 more citing papers are in PubMed but not listed here.
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Some plant cytoplasms express novel mitochondrial genes that cause male sterility. Nuclear genes that disrupt the accumulation of the corresponding mitochondrial gene products can restore fertility to such plants. The Texas (T) cytoplasm mitochondrial genome of maize expresses a novel protein, URF13, which is necessary for T cytoplasm-induced male sterility. Working in concert, functional alleles of two nuclear genes, rf1 and rf2, can restore fertility to T cytoplasm plants. Rf1 alleles, but not Rf2 alleles, reduce the accumulation of URF13. Hence, Rf2 differs from typical nuclear restorers in that it does not alter the accumulation of the mitochondrial protein necessary for T cytoplasm-induced male sterility. This study established that the rf2 gene encodes a soluble protein that accumulates in the mitochondrial matrix. Three independent lines of evidence establish that the RF2 protein is an aldehyde dehydrogenase (ALDH). The finding that T cytoplasm plants that are homozygous for the rf2-R213 allele are male sterile but accumulate normal amounts of RF2 protein that lacks normal mitochondrial (mt) ALDH activity provides strong evidence that rf2-encoded mtALDH activity is required to restore male fertility to T cytoplasm maize. Detailed genetic analyses have established that the rf2 gene also is required for anther development in normal cytoplasm maize. Hence, it appears that the rf2 gene was recruited recently to function as a nuclear restorer. ALDHs typically have very broad substrate specificities. Indeed, the RF2 protein is capable of oxidizing at least three aldehydes. Hence, the specific metabolic pathway(s) within which the rf2-encoded mtALDH acts remains to be discovered.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.