ReviewImmunologic research2000
The human thymus during aging.
Review in Immunologic research, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
54 citing papers in PubMed.
- Chemical castration of melanoma patients does not increase the frequency of tumor-specific CD4 and CD8 T cells after peptide vaccination.Journal of immunotherapy (Hagerstown, Md. : 1997) · 2013Trial
- Paracrine FGF21 dynamically modulates mTOR signaling to regulate thymus function across the lifespan.Nature aging · 2025Article
- Age-related cytokine imbalance in the thymus in sudden infant death syndrome (SIDS).Pediatric research · 2024Article
- Thymectomy for juvenile myasthenia gravis: a narrative review.Mediastinum (Hong Kong, China) · 2024Review
- An integrative mechanistic model of thymocyte dynamics.Frontiers in immunology · 2024Article
- Considerations and Approaches for Cancer Immunotherapy in the Aging Host.Cancer immunology research · 2023Review
- The burden of influenza and the role of influenza vaccination in adults aged 50-64 years: A summary of available evidence.Human vaccines & immunotherapeutics · 2023Review
- Article
- Peripheral differentiation patterns of human T cells.European journal of immunology · 2022Article
- Redox regulation of age-associated defects in generation and maintenance of T cell self-tolerance and immunity to foreign antigens.Cell reports · 2022Article
- Article
- Quantification of dendritic cell subsets in human thymus tissues of various ages.Immunity & ageing : I & A · 2021Article
- Considerations for a Respiratory Syncytial Virus Vaccine Targeting an Elderly Population.Vaccines · 2021Review
- Asymmetric cell division shapes naive and virtual memory T-cell immunity during ageing.Nature communications · 2021Article
- Curcumin protects thymus against D-galactose-induced senescence in mice.Naunyn-Schmiedeberg's archives of pharmacology · 2021Article
- Harnessing NKT cells for vaccination.Oxford open immunology · 2021Review
- Molecular Mechanisms of Premature Aging in Hemodialysis: The Complex Interplay Between Innate and Adaptive Immune Dysfunction.International journal of molecular sciences · 2020Review
- Implications of Oxidative Stress and Cellular Senescence in Age-Related Thymus Involution.Oxidative medicine and cellular longevity · 2020Review
- Temporal expression patterns of the melatoninergic system in the human thymus of children.Molecular metabolism · 2019Article
- Dynamic changes in epithelial cell morphology control thymic organ size during atrophy and regeneration.Nature communications · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The human thymus is required for establishment of a normal T cell repertoire in fetal development, as children born without a thymus (DiGeorge Syndrome) lack thymus-derived (T) and T cell immunity. While the function of the thymus in children for production of new T cells is clear, it has not been obvious that the adult thymus can produce significant numbers of new T cells. Until recently, no assays were available to directly evaluate postnatal thymic function. This paper reviews work on human thymic aging at Duke University School of Medicine and discusses the relevance of this work to devising new strategies for T cell immune reconstitution in man.
Indexed as
Identifiers
11339360What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.