ArticleLipids2001
Unique phospholipid metabolism in mouse heart in response to dietary docosahexaenoic or alpha-linolenic acids.
Article in Lipids, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed, 69 citations in OpenAlex.
- Lipidomics reveals early metabolic changes in subjects with schizophrenia: effects of atypical antipsychotics.PloS one · 2013Trial
- Long-term walnut supplementation without dietary advice induces favorable serum lipid changes in free-living individuals.European journal of clinical nutrition · 2010Trial
- Pharmacokinetics and metabolism in mouse retina of bis-allylic deuterated docosahexaenoic acid (D-DHA), a new dry AMD drug candidate.Experimental eye research · 2022Article
- Acute exercise in mice transiently remodels the hepatic lipidome in an intensity-dependent manner.Lipids in health and disease · 2020Article
- Article
- Impact of high dietary lipid intake and related metabolic disorders on the abundance and acyl composition of the unique mitochondrial phospholipid, cardiolipin.Journal of bioenergetics and biomembranes · 2014Review
- Nutritional lipidomics: molecular metabolism, analytics, and diagnostics.Molecular nutrition & food research · 2013Review
- Dietary docosahexaenoic Acid (22:6) incorporates into cardiolipin at the expense of linoleic Acid (18:2): analysis and potential implications.International journal of molecular sciences · 2012Review
- Hepatic suppression of Foxo1 and Foxo3 causes hypoglycemia and hyperlipidemia in mice.Endocrinology · 2012Article
- Deletion of betaine-homocysteine S-methyltransferase in mice perturbs choline and 1-carbon metabolism, resulting in fatty liver and hepatocellular carcinomas.The Journal of biological chemistry · 2011Article
- Prolonged QT interval and lipid alterations beyond β-oxidation in very long-chain acyl-CoA dehydrogenase null mouse hearts.American journal of physiology. Heart and circulatory physiology · 2011Article
- Article
- The plasma lipidomic signature of nonalcoholic steatohepatitis.Hepatology (Baltimore, Md.) · 2009Article
- Artificial rearing of infant mice leads to n-3 fatty acid deficiency in cardiac, neural and peripheral tissues.Lipids · 2009Article
- Effects of docosahexaenoic acid on large-conductance Ca2+-activated K+ channels and voltage-dependent K+ channels in rat coronary artery smooth muscle cells.Acta pharmacologica Sinica · 2009Article
- Article
- Metabolomic mapping of atypical antipsychotic effects in schizophrenia.Molecular psychiatry · 2007Article
- Increased oxidative stress is associated with balanced increases in hepatocyte apoptosis and proliferation in glycerol-3-phosphate acyltransferase-1 deficient mice.Experimental and molecular pathology · 2007Article
- Agpat6--a novel lipid biosynthetic gene required for triacylglycerol production in mammary epithelium.Journal of lipid research · 2006Article
- Agpat6 deficiency causes subdermal lipodystrophy and resistance to obesity.Journal of lipid research · 2006Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Diet and fatty acid metabolism interact in yet unknown ways to modulate membrane fatty acid composition and certain cellular functions. For example, dietary precursors or metabolic products of n-3 fatty acid metabolism differ in their ability to modify specific membrane components. In the present study, the effect of dietary 22:6n-3 or its metabolic precursor, 18:3n-3, on the selective accumulation of 22:6n-3 by heart was investigated. The mass and fatty acid compositions of individual phospholipids (PL) in heart and liver were quantified in mice fed either 22:6n-3 (from crocodile oil) or 18:3n-3 (from soybean oil) for 13 wk. This study was conducted to determine if the selective accumulation of 22:6n-3 in heart was due to the incorporation of 22:6n-3 into cardiolipin (CL), a PL most prevalent in heart and known to accumulate 22:6n-3. Although heart was significantly enriched with 22:6n-3 relative to liver, the accumulation of 22:6n-3 by CL in heart could not quantitatively account for this difference. CL from heart did accumulate 22:6n-3, but only in mice fed preformed 22:6n-3. Diets rich in non-22:6n-3 fatty acids result in a fatty acid composition of phosphatidylcholine (PC) in heart that is unusually enriched with 22:6n-3. In this study, the mass of PC in heart was positively correlated with the enrichment of 22:6n-3 into PC. The increased mass of PC was coincident with a decrease in the mass of phosphatidylethanolamine, suggesting that 22:6n-3 induced PC synthesis by increasing phosphatidylethanolamine-N-methyltransferase activity in the heart.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.