ArticleGenome research2001
Ancient genome duplications did not structure the human Hox-bearing chromosomes.
Article in Genome research, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
37 citing papers in PubMed, 120 citations in OpenAlex.
- The hidden Markov model and its applications in bioinformatics analysis.Genes & diseases · 2026Review
- Evolutionary history of the human multigene families reveals widespread gene duplications throughout the history of animals.BMC evolutionary biology · 2019Article
- ErbB Proteins as Molecular Target of Dietary Phytochemicals in Malignant Diseases.Journal of oncology · 2017Review
- Hox genes and evolution.F1000Research · 2016Review
- Diversification of four human HOX gene clusters by step-wise evolution rather than ancient whole-genome duplications.Development genes and evolution · 2015Review
- Statistics and truth in phylogenomics.Molecular biology and evolution · 2012Review
- Evolution of conserved non-coding sequences within the vertebrate Hox clusters through the two-round whole genome duplications revealed by phylogenetic footprinting analysis.Journal of molecular evolution · 2010Article
- Ectodermal dysplasia-cutaneous syndactyly syndrome maps to chromosome 7p21.1-p14.3.Human genetics · 2009Article
- Back to basics--how the evolution of the extracellular matrix underpinned vertebrate evolution.International journal of experimental pathology · 2009Review
- Evolution of the multifaceted eukaryotic akirin gene family.BMC evolutionary biology · 2009Article
- Multiple chromosomal rearrangements structured the ancestral vertebrate Hox-bearing protochromosomes.PLoS genetics · 2009Article
- Are we degenerate tetraploids? More genomes, new facts.Biology direct · 2008Article
- Whole-genome duplications in the ancestral vertebrate are detectable in the distribution of gene family sizes of tetrapod species.Journal of molecular evolution · 2008Article
- Early vertebrate whole genome duplications were predated by a period of intense genome rearrangement.Genome research · 2008Article
- Early vertebrate chromosome duplications and the evolution of the neuropeptide Y receptor gene regions.BMC evolutionary biology · 2008Article
- Genomic evidence for a simpler clotting scheme in jawless vertebrates.Journal of molecular evolution · 2008Article
- An insight into the phylogenetic history of HOX linked gene families in vertebrates.BMC evolutionary biology · 2007Article
- Gene-interleaving patterns of synteny in the Saccharomyces cerevisiae genome: are they proof of an ancient genome duplication event?Biology direct · 2007Article
- Quantifying the major mechanisms of recent gene duplications in the human and mouse genomes: a novel strategy to estimate gene duplication rates.Genome biology · 2007Article
- Gene duplication, gene loss and evolution of expression domains in the vertebrate nuclear receptor NR5A (Ftz-F1) family.The Biochemical journal · 2005Article
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3 authors at 1 institution in 1 country.
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Abstract
The fact that there are four homeobox (Hox) clusters in most vertebrates but only one in invertebrates is often cited as evidence for the hypothesis that two rounds of genome duplication by polyploidization occurred early in vertebrate history. In addition, it has been observed in humans and other mammals that numerous gene families include paralogs on two or more of the four Hox-bearing chromosomes (the chromosomes bearing the Hox clusters; i.e., human chromosomes 2, 7, 12, and 17), and the existence of these paralogs has been taken as evidence that these genes were duplicated along with the Hox clusters by polyploidization. We tested this hypothesis by phylogenetic analysis of 42 gene families including members on two or more of the human Hox-bearing chromosomes. In 32 of these families there was evidence against the hypothesis that gene duplication occurred simultaneously with duplication of the Hox clusters. Phylogenies of 14 families supported the occurrence of one or more gene duplications before the origin of vertebrates, and of 15 gene duplication times estimated for gene families evolving in a clock-like manner, only six were dated to the same time period early in vertebrate history during which the Hox clusters duplicated. Furthermore, of gene families duplicated around the same time as the Hox clusters, the majority showed topologies inconsistent with their having duplicated simultaneously with the Hox clusters. The results thus indicate that ancient events of genome duplication, if they occurred at all, did not play an important role in structuring the mammalian Hox-bearing chromosomes.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.