ArticleThe American journal of pathology2001
Immunopathology and ehrlichial propagation are regulated by interferon-gamma and interleukin-10 in a murine model of human granulocytic ehrlichiosis.
Article in The American journal of pathology, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
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Who cites it
40 citing papers in PubMed, 96 citations in OpenAlex.
- Comparative evaluation of oxytetracycline and an herbal formulation in the treatment of bovine anaplasmosis.Tropical animal health and production · 2026Article
- Interferon-Science (New York, N.Y.) · 2024Review
- Temporal patterns of gene expression in response to inoculation with a virulent Anaplasma phagocytophilum strain in sheep.Scientific reports · 2023Article
- Innate immunity in rickettsial infections.Frontiers in cellular and infection microbiology · 2023Review
- Article
- Epidemiological and Clinicopathological Features ofFrontiers in veterinary science · 2021Review
- Immunization against Anaplasma phagocytophilum Adhesin Binding Domains Confers Protection against Infection in the Mouse Model.Infection and immunity · 2020Article
- VirB10 vaccination for protection against Anaplasma phagocytophilum.BMC microbiology · 2018Article
- Differential Susceptibility of Male Versus Female Laboratory Mice toTropical medicine and infectious disease · 2018Article
- Article
- Interferon-γ-dependent control of Anaplasma phagocytophilum by murine neutrophil granulocytes.Parasites & vectors · 2017Article
- Influence of Genetic Background on Hematologic and Histopathologic Alterations during Acute Granulocytic Anaplasmosis in 129/SvEv and C57BL/6J Mice Lacking Type I and Type II Interferon Signaling.Comparative medicine · 2017Article
- Pro-inflammatory immune responses are associated with clinical signs and symptoms of human anaplasmosis.PloS one · 2017Article
- Pseudo-Pelger-Huët anomaly and granulocytic dysplasia associated with human granulocytic anaplasmosis.International journal of hematology · 2015Article
- The role of CD8 T lymphocytes in rickettsial infections.Seminars in immunopathology · 2015Review
- Stat1 negatively regulates immune-mediated injury with Anaplasma phagocytophilum infection.Journal of immunology (Baltimore, Md. : 1950) · 2014Article
- Comparison and characterization of granulocyte cell models for Anaplasma phagocytophilum infection.Pathogens and disease · 2014Article
- Article
- Anaplasma phagocytophilum dihydrolipoamide dehydrogenase 1 affects host-derived immunopathology during microbial colonization.Infection and immunity · 2012Article
- Adaptive immunity to Anaplasma pathogens and immune dysregulation: implications for bacterial persistence.Comparative immunology, microbiology and infectious diseases · 2012Review
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Previous studies of human granulocytic ehrlichiosis (HGE) suggest a role for host immune response in resolving infection and in causing histopathological lesions. We hypothesize that interferon (IFN)-gamma allows tissue injury that is suppressed by interleukin (IL)-10 after initiation by ehrlichia infection. Thus, parental C57BL/6, IL-10-/-, and IFN-gamma-/- strains of mice were infected and then assayed for hepatic histopathological lesions, ehrlichial burden, and cytokine responses to ehrlichial antigen in primary splenic cultures during the first 21 days after infection. Histopathological severity in C57/BL6 and IL-10-/- mice rose in parallel through day 7, but then diverged as pathology in IL-10-/- mice continued to increase and remained high throughout the course of the study. The histopathological rank of C57BL/6 of mice decreased at day 10 and returned to baseline levels at days 14 and 21. In contrast, the IFN-gamma-/- strain had baseline pathology scores throughout the course of the infection, yet had significantly higher ehrlichial burden both in the blood and tissues than C57BL/6 or IL-10-/- mice. This suggests that histopathological lesions in the HGE murine model do not result from direct ehrlichia-mediated injury but from immunopathological mechanisms initiated by ehrlichial infection. The similarities with lesions in humans suggest an immunopathological basis for HGE.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.