ArticleBritish journal of cancer2001
Relationship of hypoxia to metastatic ability in rodent tumours.
Article in British journal of cancer, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
38 citing papers in PubMed, 88 citations in OpenAlex.
- Oxygen-releasing scaffolds in tissue engineering: design strategies, fabrication and regenerative applications.Regenerative biomaterials · 2026Review
- Hypoxic microenvironment in cancer: molecular mechanisms and therapeutic interventions.Signal transduction and targeted therapy · 2023Review
- Review
- Analysis of Risk Factors for Distant Metastasis of Pancreatic Ductal Adenocarcinoma without Regional Lymph Node Metastasis and a Nomogram Prediction Model for Survival.Evidence-based complementary and alternative medicine : eCAM · 2023Article
- Two Novel Nomograms Predicting the Risk and Prognosis of Pancreatic Cancer Patients With Lung Metastases: A Population-Based Study.Frontiers in public health · 2022Article
- Vascular modulation through exercise improves chemotherapy efficacy in Ewing sarcoma.Pediatric blood & cancer · 2019Article
- Defining the Hallmarks of Metastasis.Cancer research · 2019Review
- Targeted metabolomics in colorectal cancer: a strategic approach using standardized laboratory tests of the blood and urine.Hypoxia (Auckland, N.Z.) · 2017Article
- Blood flow responses to mild-intensity exercise in ectopic vs. orthotopic prostate tumors; dependence upon host tissue hemodynamics and vascular reactivity.Journal of applied physiology (Bethesda, Md. : 1985) · 2016Article
- Tumor Heterogeneity--A 'Contemporary Concept' Founded on Historical Insights and Predictions.Cancer research · 2016Article
- Caveolin-1 in oral squamous cell carcinoma microenvironment: an overview.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2014Review
- Significance of Fractionated Administration of Thalidomide Combined With γ-Ray Irradiation in Terms of Local Tumor Response and Lung Metastasis.World journal of oncology · 2014Article
- Effect of bevacizumab combined with boron neutron capture therapy on local tumor response and lung metastasis.Experimental and therapeutic medicine · 2014Article
- Modulation of blood flow, hypoxia, and vascular function in orthotopic prostate tumors during exercise.Journal of the National Cancer Institute · 2014Article
- Usefulness of Daily Fractionated Administration of Wortmannin Combined With γ-Ray Irradiation in Terms of Local Tumor Response and Lung Metastasis.World journal of oncology · 2013Article
- Effects of employing a ¹⁰B-carrier and manipulating intratumour hypoxia on local tumour response and lung metastatic potential in boron neutron capture therapy.The British journal of radiology · 2012Article
- Reducing intratumour acute hypoxia through bevacizumab treatment, referring to the response of quiescent tumour cells and metastatic potential.The British journal of radiology · 2011Article
- Nitroxides as cancer imaging agents.Anti-cancer agents in medicinal chemistry · 2011Review
- Significance of manipulating tumour hypoxia and radiation dose rate in terms of local tumour response and lung metastatic potential, referring to the response of quiescent cell populations.The British journal of radiology · 2010Article
- Three-dimensional multispecies nonlinear tumor growth-II: Tumor invasion and angiogenesis.Journal of theoretical biology · 2010Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The relationship between tumour oxygenation in vivo and metastatic potential was investigated in 2 rodent tumour models, KHT-C fibrosarcoma and SCC-VII squamous cell carcinoma. The oxygen status in these rodent tumours transplanted intramuscularly in syngeneic mice was measured using the Eppendorf pO(2)Histograph. The results indicate a considerable heterogeneity in oxygenation between individual tumours within each tumour cell line. At different tumour sizes, animals were killed and lung lobes were examined for macroscopic and microscopic lung metastases. In the KHT-C tumours, a significant increase in early pulmonary metastasis formation was observed in mice with hypoxic primary tumours. Hypoxic SCC-VII tumours did not give rise to enhanced lung metastasis formation despite oxygenation in a range similar to the KHT-C tumours. However, the overall metastasis incidence in the SCC-VII model was very low. The results obtained in the KHT-C model, which show that hypoxic tumours are more likely to metastasize, are in agreement with recent clinical data suggesting that a hypoxic environment might be implicated in metastatic ability of human tumours.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.