ArticleBritish journal of cancer2001
Kupffer cells of cirrhotic rat livers sensitize colon cancer cells to Fas-mediated apoptosis.
Article in British journal of cancer, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 33 citations in OpenAlex.
- Patients with chronically diseased livers have lower incidence of colorectal liver metastases: a meta-analysis.PloS one · 2014Pooled it
- Impact of Underlying Liver Disease on the Risk and Prognostic Factors of Breast Cancer Liver Metastases: A Retrospective Multicenter Cohort Study.Cancer medicine · 2026Article
- Review
- Association between Hepatitis B virus infection and liver metastasis in colorectal cancer.MedComm · 2024Article
- Fatty change of the liver microenvironment influences the metastatic potential of colorectal cancer.International journal of experimental pathology · 2020Article
- IEO model: A novel concept describing the complete metastatic process in the liver microenvironment.Oncology letters · 2020Review
- Effect of Non-alcoholic Fatty Liver Disease on the Risk of Synchronous Liver Metastasis: Analysis of 451 Consecutive Patients of Newly Diagnosed Colorectal Cancer.Frontiers in oncology · 2020Article
- Impact of Hepatitis B Carrier Status on the Outcomes of Surgical Treatment of Colorectal Liver Metastases.World journal of surgery · 2018Article
- Oncologic and surgical outcomes in colorectal cancer patients with liver cirrhosis: A propensity-matched study.PloS one · 2017Article
- The liver prometastatic reaction of cancer patients: implications for microenvironment-dependent colon cancer gene regulation.Cancer microenvironment : official journal of the International Cancer Microenvironment Society · 2011Article
- Role of Kupffer cells in the pathogenesis of liver disease.World journal of gastroenterology · 2006Review
- Expression of FAP-1 by human colon adenocarcinoma: implication for resistance against Fas-mediated apoptosis in cancer.British journal of cancer · 2004Article
- Pathomorphological study on location and distribution of Kupffer cells in hepatocellular carcinoma.World journal of gastroenterology · 2003Article
- Kupffer cells promote lead nitrate-induced hepatocyte apoptosis via oxidative stress.Comparative hepatology · 2003Article
- Soluble Fas ligand released by colon adenocarcinoma cells induces host lymphocyte apoptosis: an active mode of immune evasion in colon cancer.British journal of cancer · 2001Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Metastasis of colorectal carcinomas rarely occurs in cirrhotic livers. Our study investigated the influence of activated Kupffer cells from cirrhotic rat livers on hepatic colonization and FasR-mediated apoptosis of colon cancer cells. A rat colon cancer cell line, RCN-9, was used to inoculate rat livers. Treatment with conditioned media of Kupffer cells isolated from CCl(4)-induced cirrhotic rat livers (cirrhotic KCM) significantly reduced the incidence of hepatic colonization of RCN-9 cells. In vitro cytotoxicity of Kupffer cells and tumour infiltrating lymphocytes (TILs) on RCN-9 cells was evaluated using [(3)H]-release assay. RCN-9 cells were resistant to cytotoxicity mediated by cirrhotic Kupffer cells, but were sensitized to TIL-mediated killing after treatment with cirrhotic KCM. The specific killing induced by TILs was FasR-mediated, as it was inhibited by ZB4, an antagonistic anti-FasR antibody. In agreement, cirrhotic KCM increased recombinant Fas ligand-induced apoptosis of RCN-9 cells, and up-regulated FasR expression on RCN-9 cells as evaluated by RT-PCR and flow cytometry. These findings suggest that Kupffer cells in cirrhotic livers sensitize metastatic colon cancer cells to FasR-mediated apoptosis by up-regulating the receptors, which thus prepare them to be eliminated by infiltrating lymphocytes.
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