ArticleEnvironmental health perspectives2001
Measurement of organophosphate metabolites in postpartum meconium as a potential biomarker of prenatal exposure: a validation study.
Article in Environmental health perspectives, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 56 papers.
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Who cites it
56 citing papers in PubMed, 159 citations in OpenAlex.
- Maternal organophosphate pesticide exposure in relation to birthweight: Modification by placenta transporter genotype.Placenta · 2025Article
- Profiling the cytotoxic effects of naled and other pesticides in primary human placental cytotrophoblasts.Toxicological sciences : an official journal of the Society of Toxicology · 2025Article
- A birth cohort observational study to assess the association of prenatal biomarkers of organophosphates with visual attention, recognition memory and information processing among Thai infants.Environmental research · 2025Observational
- Prenatal organophosphate pesticide exposure and sex-specific estimated fetal size.American journal of epidemiology · 2025Article
- Metabolomic and proteomic characterization of sng and pain phenotypes in fibromyalgia.European journal of pain (London, England) · 2022Article
- The relationship between prenatal exposure to organophosphate insecticides and neurodevelopmental integrity of infants at 5-weeks of age.Frontiers in epidemiology · 2022Article
- Quantification of glyphosate and other organophosphorus compounds in human urine via ion chromatography isotope dilution tandem mass spectrometry.Chemosphere · 2021Article
- Integrating biokinetics and in vitro studies to evaluate developmental neurotoxicity induced by chlorpyrifos in human iPSC-derived neural stem cells undergoing differentiation towards neuronal and glial cells.Reproductive toxicology (Elmsford, N.Y.) · 2020Article
- ORGANOPHOSPHATES IN MECONIUM OF NEWBORN BABIES WHOSE MOTHERS RESIDED IN AGRICULTURAL AREAS OF THAILAND.The Southeast Asian journal of tropical medicine and public health · 2020Article
- The association between maternal exposure to organophosphate pesticides and neonatal anthropometric measures: A systematic review and meta-analysis.Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences · 2020Review
- Method Development for Effect-Directed Analysis of Endocrine Disrupting Compounds in Human Amniotic Fluid.Environmental science & technology · 2019Article
- Evaluation of chlorpyrifos residue in breast milk and its metabolite in urine of mothers and their infants feeding exclusively by breast milk in north of Iran.Journal of environmental health science & engineering · 2019Article
- Organophosphorus pesticide determination in biological specimens: bioanalytical and toxicological aspects.International journal of legal medicine · 2019Review
- Differences in testosterone and its precursors by sex of the offspring in meconium.The Journal of steroid biochemistry and molecular biology · 2017Article
- A single method for detecting 11 organophosphate pesticides in human plasma and breastmilk using GC-FPD.Journal of chromatography. B, Analytical technologies in the biomedical and life sciences · 2016Article
- Animal models of gene-environment interaction in schizophrenia: A dimensional perspective.Progress in neurobiology · 2016Review
- Chlorpyrifos and neurodevelopmental effects: a literature review and expert elicitation on research and policy.Environmental health : a global access science source · 2012Review
- Urinary concentrations of dialkylphosphate metabolites of organophosphorus pesticides: National Health and Nutrition Examination Survey 1999-2004.International journal of environmental research and public health · 2011Article
- Chlorpyrifos-oxon disrupts zebrafish axonal growth and motor behavior.Toxicological sciences : an official journal of the Society of Toxicology · 2011Article
- The implications of using a physiologically based pharmacokinetic (PBPK) model for pesticide risk assessment.Environmental health perspectives · 2010Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Experimental data have linked exposure to prenatal organophosphates to adverse neurocognitive sequalae. However, epidemiologic research has been hampered by lack of reliable dosimeters. Existing biomarkers reflect short-term exposure only. Measurements of pesticides in postpartum meconium may yield a longer-term dosimeter of prenatal exposure. As the initial step in biomarker validation, this research determined background levels, detection limits, and stabilities of six organophosphate metabolites in meconium: diethylphosphate (DEP), diethylthiophosphate (DETP), diethyldithiophosphate (DEDTP), dimethylphosphate (DMP), dimethylthiophosphate (DMTP), and dimethyldithiophosphate (DMDTP). Calibration curves were also constructed. The meconium was collected from 20 newborns at New York Presbyterian Hospital; analyses were undertaken at the Centers for Disease Control and Prevention (CDC). DEP was detected in 19/20 samples (range 0.8-3.2 microg/g) and DETP was detected in 20/20 (range 2.0-5.6 microg/g). DMP and DEDTP were each detected in 1/20 (at 16 and 1.8 microg/g, respectively). DMTP and DMDTP were not detected. Detection limits were comparable to or lower than those in urine; levels were similar to those seen in adult urine in population-based research. Metabolites were stable at room temperature over 12 hr. Calibration curves were linear over the range tested (0.5-400 microg/g); recoveries ranged from 18% to 66%. Using isotope dilution, recoveries of each analyte in individual samples can be corrected automatically based on the recovery of the respective stable isotope-labeled analogue, making this method fully quantitative. Results indicate that measurements of organophosphate metabolites in meconium have promise as biomarkers of prenatal exposure. Further research is needed to determine the time frame of exposure represented by pesticide levels in meconium and to evaluate the dose-response relationship.
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