ArticleGenetics2001
Evidence for selection at the fused1 locus of Drosophila americana.
Article in Genetics, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
13 citing papers in PubMed, 30 citations in OpenAlex.
- Origin and Consequences of Chromosomal Inversions in the virilis Group of Drosophila.Genome biology and evolution · 2018Article
- Article
- Drosophila americana as a model species for comparative studies on the molecular basis of phenotypic variation.Genome biology and evolution · 2013Article
- Selection on codon usage and base composition in Drosophila americana.Biology letters · 2012Article
- Article
- Polytene chromosomal maps of 11 Drosophila species: the order of genomic scaffolds inferred from genetic and physical maps.Genetics · 2008Article
- Positive selection near an inversion breakpoint on the neo-X chromosome of Drosophila americana.Genetics · 2007Article
- Patterns of molecular variation and evolution in Drosophila americana and its relatives.Genetics · 2007Article
- Article
- The evolutionary history of the transposable element Penelope in the Drosophila virilis group of species.Journal of molecular evolution · 2006Article
- Article
- Sequence differentiation associated with an inversion on the neo-X chromosome of Drosophila americana.Genetics · 2003Article
- Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We analyze genetic variation at fused1, a locus that is close to the centromere of the X chromosome-autosome (X/4) fusion in Drosophila americana. In contrast to other X-linked and autosomal genes, for which a lack of population subdivision in D. americana has been observed at the DNA level, we find strong haplotype structure associated with the alternative chromosomal arrangements. There are several derived fixed differences at fused1 (including one amino acid replacement) between two haplotype classes of this locus. From these results, we obtain an estimate of an age of approximately 0.61 million years for the origin of the two haplotypes of the fused1 gene. Haplotypes associated with the X/4 fusion have less DNA sequence variation at fused1 than haplotypes associated with the ancestral chromosome arrangement. The X/4 haplotypes also exhibit clinal variation for the allele frequencies of the three most common amino acid replacement polymorphisms, but not for adjacent silent polymorphisms. These patterns of variation are best explained as a result of selection acting on amino acid substitutions, with geographic variation in selection pressures.
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