ArticleGenetics2001
Protosilencers in Saccharomyces cerevisiae subtelomeric regions.
Article in Genetics, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- Transcriptional silencing in Saccharomyces cerevisiae: known unknowns.Epigenetics & chromatin · 2024Review
- Elimination of subtelomeric repeat sequences exerts little effect on telomere essential functions ineLife · 2024Article
- tRNA Genes Affect Chromosome Structure and Function via Local Effects.Molecular and cellular biology · 2019Article
- Article
- The three clades of the telomere-associated TLO gene family of Candida albicans have different splicing, localization, and expression features.Eukaryotic cell · 2012Article
- A protosilencer of subtelomeric gene expression in Candida glabrata with unique properties.Genetics · 2012Article
- Functions of protosilencers in the formation and maintenance of heterochromatin in Saccharomyces cerevisiae.PloS one · 2012Article
- Sub-telomeric core X and Y' elements in S. cerevisiae suppress extreme variations in gene silencing.PloS one · 2011Article
- Dot1 binding induces chromatin rearrangements by histone methylation-dependent and -independent mechanisms.Epigenetics & chromatin · 2011Article
- The association of yKu with subtelomeric core X sequences prevents recombination involving telomeric sequences.Genetics · 2009Article
- Subtelomeric ACS-containing proto-silencers act as antisilencers in replication factors mutants in Saccharomyces cerevisiae.Molecular biology of the cell · 2009Article
- Long-range communication between the silencers of HMR.Molecular and cellular biology · 2008Article
- Subtelomeric elements influence but do not determine silencing levels at Saccharomyces cerevisiae telomeres.Genetics · 2007Article
- Differential requirement of DNA replication factors for subtelomeric ARS consensus sequence protosilencers in Saccharomyces cerevisiae.Genetics · 2006Article
- Position effect on the directionality of silencer function in Saccharomyces cerevisiae.Genetics · 2006Article
- Subtelomeric factors antagonize telomere anchoring and Tel1-independent telomere length regulation.The EMBO journal · 2006Article
- The central roles of telomeres and subtelomeres in antigenic variation in African trypanosomes.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2005Review
- A methyltransferase targeting assay reveals silencer-telomere interactions in budding yeast.Molecular and cellular biology · 2003Article
- Transcriptional silencing in Saccharomyces cerevisiae and Schizosaccharomyces pombe.Nucleic acids research · 2002Review
- Domains of gene silencing near the left end of chromosome III in Saccharomyces cerevisiae.Genetics · 2002Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Saccharomyces cerevisiae subtelomeric repeats contain silencing elements such as the core X sequence, which is present at all chromosome ends. When transplaced at HML, core X can enhance the action of a distant silencer without acting as a silencer on its own, thus fulfilling the functional definition of a protosilencer. Here we show that an ACS motif and an Abf1p-binding site participate in the silencing capacity of core X and that their effects are additive. In addition, in a variety of settings, core X was found to bring about substantial gene repression only when a low level of silencing was already detectable in its absence. Adjoining an X-STAR sequence, which naturally abuts core X in subtelomeric regions, did not improve the silencing capacity of core X. We propose that protosilencers play a major role in a variety of silencing phenomena, as is the case for core X, which acts as a silencing relay, prolonging silencing propagation away from telomeres.
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