ArticleProceedings of the National Academy of Sciences of the United States of America2001
Phenotypic consequences of lung-specific inducible expression of FGF-3.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
11 citing papers in PubMed, 40 citations in OpenAlex.
- Steroid-induced fibroblast growth factors drive an epithelial-mesenchymal inflammatory axis in severe asthma.Science translational medicine · 2022Article
- Kinase domain activation of FGFR2 yields high-grade lung adenocarcinoma sensitive to a Pan-FGFR inhibitor in a mouse model of NSCLC.Cancer research · 2014Article
- Rapid induction of lung adenocarcinoma by fibroblast growth factor 9 signaling through FGF receptor 3.Cancer research · 2013Article
- Association of a FGFR-4 gene polymorphism with bronchopulmonary dysplasia and neonatal respiratory distress.Disease markers · 2013Article
- Progressive myopathy in an inducible mouse model of oculopharyngeal muscular dystrophy.Neurobiology of disease · 2012Article
- Blocking the glucocorticoid receptor with RU-486 does not prevent glucocorticoid control of autoimmune mouse hearing loss.Audiology & neuro-otology · 2009Article
- Article
- p63 is the molecular switch for initiation of an epithelial stratification program.Genes & development · 2004Article
- Inducible expression of FGF-3 in mouse mammary gland.Proceedings of the National Academy of Sciences of the United States of America · 2002Article
- Ectopic expression of FGF-3 results in abnormal prostate and Wolffian duct development.Oncogene · 2002Article
- Induction and apoptotic regression of lung adenocarcinomas by regulation of a K-Ras transgene in the presence and absence of tumor suppressor genes.Genes & development · 2001Article
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
Abstract
Members of the fibroblast growth factor (FGF) family play a critical role in embryonic lung development and adult lung physiology. The in vivo investigation of the role FGFs play in the adult lung has been hampered because the constitutive pulmonary expression of these factors often has deleterious effects and frequently results in neonatal lethality. To circumvent these shortcomings, we expressed FGF-3 in the lungs under the control of the progesterone antagonist-responsive binary transgenic system. Four binary transgenic lines were obtained that showed ligand-dependent induction of FGF-3 with induced levels of FGF-3 expression dependent on the levels of expression of the GLp65 regulator as well as the dose of the progesterone antagonist, RU486, administered. FGF-3 expression in the adult mouse lung resulted in two phenotypes depending on the levels of induction of FGF-3. Low levels of FGF-3 expression resulted in massive free alveolar macrophage infiltration. High levels of FGF-3 expression resulted in diffuse alveolar type II cell hyperplasia. Both phenotypes were reversible after the withdrawal of RU486. This system will be a valuable means of investigating the diverse roles of FGFs in the adult lung.
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