ArticleProceedings of the National Academy of Sciences of the United States of America2001
Structure of melanoma inhibitory activity protein, a member of a recently identified family of secreted proteins.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 56 citations in OpenAlex.
- Evaluation of Polar Substituted Schiff Bases and 1,2,3-Triazole Hybrids as Anticancer Agents.Chemistry & biodiversity · 2025Article
- Melanoma's New Frontier: Exploring the Latest Advances in Blood-Based Biomarkers for Melanoma.Cancers · 2024Review
- 1,2,3-triazole and chiral Schiff base hybrids as potential anticancer agents: DFT, molecular docking and ADME studies.Scientific reports · 2024Article
- Characterization of a fold in TANGO1 evolved from SH3 domains for the export of bulky cargos.Nature communications · 2023Article
- Article
- Significance of 5-International journal of molecular sciences · 2020Review
- Human melanoma inhibitory protein binds to the FN12-14 Hep II domain of fibronectin.Biointerphases · 2017Article
- Small Molecules Antagonise the MIA-Fibronectin Interaction in Malignant Melanoma.Scientific reports · 2016Article
- Matrix assisted laser desorption ionization mass spectrometry imaging identifies markers of ageing and osteoarthritic cartilage.Arthritis research & therapy · 2014Article
- Structure of HHARI, a RING-IBR-RING ubiquitin ligase: autoinhibition of an Ariadne-family E3 and insights into ligation mechanism.Structure (London, England : 1993) · 2013Article
- Targeting melanoma metastasis and immunosuppression with a new mode of melanoma inhibitory activity (MIA) protein inhibition.PloS one · 2012Article
- Reduced cholesterol and triglycerides in mice with a mutation in Mia2, a liver protein that localizes to ER exit sites.Journal of lipid research · 2011Article
- Protein export at the ER: loading big collagens into COPII carriers.The EMBO journal · 2011Review
- Global defects in collagen secretion in a Mia3/TANGO1 knockout mouse.The Journal of cell biology · 2011Article
- Modulation of cartilage differentiation by melanoma inhibiting activity/cartilage-derived retinoic acid-sensitive protein (MIA/CD-RAP).Experimental & molecular medicine · 2010Article
- A genome-wide RNA interference screen identifies two novel components of the metazoan secretory pathway.The EMBO journal · 2010Article
- Analysis on conservation of disulphide bonds and their structural features in homologous protein domain families.BMC structural biology · 2008Article
- CUSP: an algorithm to distinguish structurally conserved and unconserved regions in protein domain alignments and its application in the study of large length variations.BMC structural biology · 2008Article
- Misexpression of MIA disrupts lung morphogenesis and causes neonatal death.Developmental biology · 2008Article
- Structure of glutamate carboxypeptidase II, a drug target in neuronal damage and prostate cancer.The EMBO journal · 2006Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Melanoma inhibitory activity (MIA) is a 12-kDa protein that is secreted from both chondrocytes and malignant melanoma cells. MIA has been reported to have effects on cell growth and adhesion, and it may play a role in melanoma metastasis and cartilage development. We report the 1.4-A crystal structure of human MIA, which consists of an Src homology 3 (SH3)-like domain with N- and C-terminal extensions of about 20 aa. each. The N- and C-terminal extensions add additional structural elements to the SH3 domain, forming a previously undescribed fold. MIA is a representative of a recently identified family of proteins and is the first structure of a secreted protein with an SH3 subdomain. The structure also suggests a likely protein interaction site and suggests that, unlike conventional SH3 domains, MIA does not recognize polyproline helices.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.