ArticleThe EMBO journal2001
A proline-rich protein binds to the localization element of Xenopus Vg1 mRNA and to ligands involved in actin polymerization.
Article in The EMBO journal, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed, 84 citations in OpenAlex.
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- Remnants of the Balbiani body are required for formation of RNA transport granules iniScience · 2022Article
- Ciphers and Executioners: How 3'-Untranslated Regions Determine the Fate of Messenger RNAs.Frontiers in genetics · 2019Review
- Modeling microtubule-based transport and anchoring of mRNA.SIAM journal on applied dynamical systems · 2018Article
- Hermes (Rbpms) is a Critical Component of RNP Complexes that Sequester Germline RNAs during Oogenesis.Journal of developmental biology · 2016Article
- Article
- Rice MEL2, the RNA recognition motif (RRM) protein, binds in vitro to meiosis-expressed genes containing U-rich RNA consensus sequences in the 3'-UTR.Plant molecular biology · 2015Article
- Small ubiquitin-like modifier (SUMO)-mediated repression of the Xenopus Oocyte 5 S rRNA genes.The Journal of biological chemistry · 2014Article
- Oocyte polarity requires a Bucky ball-dependent feedback amplification loop.Development (Cambridge, England) · 2014Article
- The splicing activator DAZAP1 integrates splicing control into MEK/Erk-regulated cell proliferation and migration.Nature communications · 2014Article
- RNA localization in Xenopus oocytes uses a core group of trans-acting factors irrespective of destination.RNA (New York, N.Y.) · 2013Article
- DAZAP1, an RNA-binding protein required for development and spermatogenesis, can regulate mRNA translation.RNA (New York, N.Y.) · 2011Article
- Isolation and identification of cytoskeleton-associated prolamine mRNA binding proteins from developing rice seeds.Planta · 2010Article
- Participation of Xenopus Elr-type proteins in vegetal mRNA localization during oogenesis.The Journal of biological chemistry · 2009Article
- Vg1RBP phosphorylation by Erk2 MAP kinase correlates with the cortical release of Vg1 mRNA during meiotic maturation of Xenopus oocytes.RNA (New York, N.Y.) · 2009Article
- DAZAP1, an hnRNP protein, is required for normal growth and spermatogenesis in mice.RNA (New York, N.Y.) · 2008Article
- PTB/hnRNP I is required for RNP remodeling during RNA localization in Xenopus oocytes.Molecular and cellular biology · 2008Article
- VICKZ proteins mediate cell migration via their RNA binding activity.RNA (New York, N.Y.) · 2007Article
- FBPs are calibrated molecular tools to adjust gene expression.Molecular and cellular biology · 2006Article
- A novel nucleocytoplasmic shuttling sequence of DAZAP1, a testis-abundant RNA-binding protein.RNA (New York, N.Y.) · 2006Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A 340 nucleotide element within the 3' untranslated region of Vg1 mRNA determines its localization to the vegetal cortex of Xenopus oocytes. To identify protein factors that bind to this region, we screened a cDNA expression library with an RNA probe containing this sequence. Five independent isolates encoded a protein (designated Prrp for proline-rich RNA binding protein) having two RNP domains followed by multiple polyproline segments. Prrp and Vg1 mRNAs are co-localized to the vegetal cortex of stage IV oocytes, substantiating an interaction between the two in vivo. Prrp also associates with VegT mRNA, which like Vg1 mRNA uses the late localization pathway, but not with Xcat-2 or Xwnt-11 mRNAs, which use the early pathway. The proline-rich domain of Prrp interacts with profilin, a protein that promotes actin polymerization. Prrp can also associate with the EVH1 domain of Mena, another microfilament-associated protein. Since the anchoring of Vg1 mRNA to the vegetal cortex is actin dependent, one function of Prrp may be to facilitate local actin polymerization, representing a novel function for an RNA binding protein.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.