ArticleThe EMBO journal2001
Local action of long-range repressors in the Drosophila embryo.
Article in The EMBO journal, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
18 citing papers in PubMed, 33 citations in OpenAlex.
- Integration of Wnt and FGF signaling in theDevelopment (Cambridge, England) · 2019Article
- Genome-wide errant targeting by Hairy.eLife · 2015Article
- Recent insights into Groucho co-repressor recruitment and function.Transcription · 2015Article
- Context-dependent enhancer selection confers alternate modes of notch regulation on argos.Molecular and cellular biology · 2014Article
- Computational identification of diverse mechanisms underlying transcription factor-DNA occupancy.PLoS genetics · 2013Article
- Complex interactions between cis-regulatory modules in native conformation are critical for Drosophila snail expression.Development (Cambridge, England) · 2011Article
- Degringolade, a SUMO-targeted ubiquitin ligase, inhibits Hairy/Groucho-mediated repression.The EMBO journal · 2011Article
- The gap gene network.Cellular and molecular life sciences : CMLS · 2011Review
- Spatial epigenetic control of mono- and bistable gene expression.PLoS biology · 2010Article
- Groucho corepressor functions as a cofactor for the Knirps short-range transcriptional repressor.Proceedings of the National Academy of Sciences of the United States of America · 2009Article
- Spreading of a corepressor linked to action of long-range repressor hairy.Molecular and cellular biology · 2008Article
- Differential in vivo requirements for oligomerization during Groucho-mediated repression.EMBO reports · 2008Article
- Structurally related Arabidopsis ANGUSTIFOLIA is functionally distinct from the transcriptional corepressor CtBP.Development genes and evolution · 2007Article
- Role of the C-terminal binding protein PXDLS motif binding cleft in protein interactions and transcriptional repression.Molecular and cellular biology · 2006Article
- Hairless-mediated repression of notch target genes requires the combined activity of Groucho and CtBP corepressors.Molecular and cellular biology · 2005Article
- cis-regulatory logic of short-range transcriptional repression in Drosophila melanogaster.Molecular and cellular biology · 2005Article
- CtBP-independent repression in the Drosophila embryo.Molecular and cellular biology · 2003Article
- The ANGUSTIFOLIA gene of Arabidopsis, a plant CtBP gene, regulates leaf-cell expansion, the arrangement of cortical microtubules in leaf cells and expression of a gene involved in cell-wall formation.The EMBO journal · 2002Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Previous studies have identified two corepressors in the early Drosophila embryo: Groucho and dCTBP: Both proteins are recruited to the DNA template by interacting with short peptide motifs conserved in a variety of sequence-specific transcriptional repressors. Once bound to DNA, Groucho appears to mediate long-range repression, while dCtBP directs short-range repression. The short-range Krüppel repressor was converted into a long-range repressor by replacing the dCtBP interaction motif (PxDLSxH) with a Groucho motif (WRPW). The resulting chimeric repressor causes a different mutant phenotype from that of the native Krüppel protein when misexpressed in transgenic embryos. The different patterning activities can be explained on the basis of long-range silencing within the hairy 5' regulatory region. The analysis of a variety of synthetic transgenes provides evidence that Groucho-dependent long-range repressors do not always cause the dominant silencing of linked enhancers within a complex cis-regulatory region. We suggest a "hot chromatin" model, whereby repressors require activators to bind DNA.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.