ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2001
Analysis of the activity-deprived zebrafish mutant macho reveals an essential requirement of neuronal activity for the development of a fine-grained visuotopic map.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 80 citations in OpenAlex.
- Ocular Necessities: A Neuroethological Perspective on Vertebrate Visual Development.Brain, behavior and evolution · 2024Review
- Live imaging of retinotectal mapping reveals topographic map dynamics and a previously undescribed role for Contactin 2 in map sharpening.Development (Cambridge, England) · 2021Article
- Retinal Axon Interplay for Binocular Mapping.Frontiers in neural circuits · 2021Article
- Experience-dependent development of visual sensitivity in larval zebrafish.Scientific reports · 2019Article
- Rules for Shaping Neural Connections in the Developing Brain.Frontiers in neural circuits · 2016Review
- Development of functional hindbrain oculomotor circuitry independent of both vascularization and neuronal activity in larval zebrafish.Current neurobiology · 2016Article
- pigk Mutation underlies macho behavior and affects Rohon-Beard cell excitability.Journal of neurophysiology · 2015Article
- Deletion of a kinesin I motor unmasks a mechanism of homeostatic branching control by neurotrophin-3.eLife · 2015Article
- Article
- Direction selectivity in the visual system of the zebrafish larva.Frontiers in neural circuits · 2013Review
- Endogenous patterns of activity are required for the maturation of a motor network.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2011Article
- Development of single retinofugal axon arbors in normal and β2 knock-out mice.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2011Article
- Identifying roles for neurotransmission in circuit assembly: insights gained from multiple model systems and experimental approaches.BioEssays : news and reviews in molecular, cellular and developmental biology · 2011Review
- Synaptic activity and activity-dependent competition regulates axon arbor maturation, growth arrest, and territory in the retinotectal projection.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2010Article
- Learning to see: patterned visual activity and the development of visual function.Trends in neurosciences · 2010Review
- Genetic Analysis of the Touch Response in Zebrafish (International journal of comparative psychology · 2010Article
- Analysis of the retina in the zebrafish model.Methods in cell biology · 2010Article
- A multi-component model of the developing retinocollicular pathway incorporating axonal and synaptic growth.PLoS computational biology · 2009Article
- Defective glycinergic synaptic transmission in zebrafish motility mutants.Frontiers in molecular neuroscience · 2009Article
- The development of motor coordination in Drosophila embryos.Development (Cambridge, England) · 2008Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The formation of a retinotopic map is thought to involve an activity-independent molecular phase for early steps of both axon pathfinding and projection and a later phase in which cross talk between retinal ganglion cells (RGCs) and tectal neurons modifies and refines the neuronal connections. We report that the maturation of the retinotopic map in the zebrafish tectum involves activity-dependent processes. Zebrafish larvae mutant for the gene macho (mao) lack neuronal activity in RGCs and also display an enlarged retinotectal projection field but no significant increase in single axon length. This morphological defect can be phenocopied by raising larvae under TTX-induced neural impulse blockade. The effect of activity deprivation is dependent on the developmental stage. The projection phenotype in mao as well as in the TTX-treated larvae develops between 4 and 6 d post-fertilization (dpf), after complete tectal coverage is first achieved. Electrophysiological recordings of RGCs in wild-type and mao zebrafish larvae reveal a temporally regulated reduction of sodium current in the mutant between 5 and 6 dpf. This coincides with the time of the axonal projection shifting on the tectum to compensate for the disparate growth patterns of the retina and the tectum. Our genetic and physiological analyses suggest a model in which neuronal activity in RGCs is needed for the establishment of morphological plasticity.
Indexed as
Identifiers
11331383PMC6762499W2120904665What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.