ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2001
Pituitary control of BK potassium channel function and intrinsic firing properties of adrenal chromaffin cells.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
What it found
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Who cites it
34 citing papers in PubMed, 79 citations in OpenAlex.
- Article
- Roles of NaPflugers Archiv : European journal of physiology · 2018Review
- Methamphetamine Regulation of Firing Activity of Dopamine Neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Article
- Knockout of the BK β4-subunit promotes a functional coupling of BK channels and ryanodine receptors that mediate a fAHP-induced increase in excitability.Journal of neurophysiology · 2016Article
- Incorporating spike-rate adaptation into a rate code in mathematical and biological neurons.Journal of neurophysiology · 2016Article
- Transient BK outward current enhances motoneurone firing rates during Drosophila larval locomotion.The Journal of physiology · 2015Article
- Knockout of the BK β2 subunit reveals the importance of accessorizing your channel.The Journal of general physiology · 2014Article
- Article
- Palmitoylation and membrane association of the stress axis regulated insert (STREX) controls BK channel regulation by protein kinase C.The Journal of biological chemistry · 2012Article
- Acute stress induces down-regulation of large-conductance Ca2+-activated potassium channels in the lateral amygdala.The Journal of physiology · 2012Article
- Splicing of the rSlo gene affects the molecular composition and drug response of Ca2+-activated K+ channels in skeletal muscle.PloS one · 2012Article
- Alternatively spliced domains interact to regulate BK potassium channel gating.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
- Long-duration perforated patch recordings from spinal interneurons of adult mice.Journal of neurophysiology · 2011Article
- Contribution of BK channels to action potential repolarisation at minimal cytosolic Ca2+ concentration in chromaffin cells.Pflugers Archiv : European journal of physiology · 2011Article
- Modulation by the BK accessory β4 subunit of phosphorylation-dependent changes in excitability of dentate gyrus granule neurons.The European journal of neuroscience · 2011Article
- Homeostatic control of neural activity: a Drosophila model for drug tolerance and dependence.International review of neurobiology · 2011Review
- Cloning and distribution of Ca2+-activated K+ channels in lobster Panulirus interruptus.Neuroscience · 2010Article
- BK channels play a counter-adaptive role in drug tolerance and dependence.Proceedings of the National Academy of Sciences of the United States of America · 2010Article
- An alpha-catulin homologue controls neuromuscular function through localization of the dystrophin complex and BK channels in Caenorhabditis elegans.PLoS genetics · 2010Article
- BKbeta1 subunits contribute to BK channel diversity in rat hypothalamic neurons.Cellular and molecular neurobiology · 2010Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
The discovery that the hypothalamic-pituitary-adrenocortical (HPA) endocrine stress axis controls an alternative splicing decision in chromaffin Slo-encoded BK (big potassium) channels raised the possibility that activation of the HPA could serve as a mechanism to tune the intrinsic electrical properties of epinephrine-secreting adrenal chromaffin cells. To test this, we compared BK functional properties and cell excitability in chromaffin cells from normal and hypophysectomized (pituitary-ablated) rats. Hypophysectomy was found to alter the voltage dependence and kinetics of BK gating, making channels less accessible for activation from rest. Perforated-patch recordings revealed changes in action potential waveform and repetitive firing properties. The maximum number of spikes that could be elicited with a 2 sec depolarizing current pulse was reduced by approximately 50% by hypophysectomy. The results indicate that pituitary hormones can adapt the mechanics of adrenal catecholamine release by tailoring BK channel function.
Indexed as
Identifiers
11331373PMC6762506W1517099987What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.