ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2001
Semaphorin 3A-vascular endothelial growth factor-165 balance mediates migration and apoptosis of neural progenitor cells by the recruitment of shared receptor.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 70 papers.
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Who cites it
70 citing papers in PubMed, 228 citations in OpenAlex.
- Neonatal diethylstilbestrol exposure disrupts uterine epithelial apical-basal polarity and partial EMT state.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Research Advances in Neuroblast Migration in Traumatic Brain Injury.Molecular neurobiology · 2024Review
- Semaphorin‑3A alleviates cardiac hypertrophy by regulating autophagy.Experimental and therapeutic medicine · 2024Article
- Article
- Perspectives and potential approaches for targeting neuropilin 1 in SARS-CoV-2 infection.Molecular medicine (Cambridge, Mass.) · 2021Review
- Microsurgical Neurovascular Anatomy of the Brain: The Posterior Circulation (Part II).Acta bio-medica : Atenei Parmensis · 2021Review
- Semaphorins in Adult Nervous System Plasticity and Disease.Frontiers in synaptic neuroscience · 2021Review
- Semaphorin 3A mediated brain tumor stem cell proliferation and invasion in EGFRviii mutant gliomas.BMC cancer · 2020Article
- Neuropilin-1 expression in GnRH neurons regulates prepubertal weight gain and sexual attraction.The EMBO journal · 2020Article
- Expression of class III Semaphorins and their receptors in the developing chicken (Gallus gallus) inner ear.The Journal of comparative neurology · 2019Article
- Class-3 Semaphorins and Their Receptors: Potent Multifunctional Modulators of Tumor Progression.International journal of molecular sciences · 2019Review
- Vascularization Strategies for Peripheral Nerve Tissue Engineering.Anatomical record (Hoboken, N.J. : 2007) · 2018Review
- Fyn-dependent phosphorylation of PlexinA1 and PlexinA2 at conserved tyrosines is essential for zebrafish eye development.The FEBS journal · 2018Article
- MicroRNA-143 and -145 modulate the phenotype of synovial fibroblasts in rheumatoid arthritis.Experimental & molecular medicine · 2017Article
- Semaphorin3A-neuropilin1 signalling is involved in the generation of cortical interneurons.Brain structure & function · 2017Article
- Ischemia reduces inter-alpha inhibitor proteins in the brain of the ovine fetus.Developmental neurobiology · 2017Article
- An Overview of the Mechanisms of Abnormal GABAergic Interneuronal Cortical Migration Associated with Prenatal Ethanol Exposure.Neurochemical research · 2017Review
- Semaphorin 3A is a retrograde cell death signal in developing sympathetic neurons.Development (Cambridge, England) · 2016Article
- Cartilage oligomeric matrix protein enhances the vascularization of acellular nerves.Neural regeneration research · 2016Article
- PlexinD1 is required for proper patterning of the periocular vascular network and for the establishment of corneal avascularity during avian ocular development.Developmental biology · 2016Article
10 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The dynamic and coordinated interaction between cells and their microenvironment controls cell migration, proliferation, and apoptosis, mediated by different cell surface molecules. We have studied the response of a neuroectodermal progenitor cell line, Dev, to a guidance molecule, semaphorin 3A (Sema3A), described previously as a repellent-collapsing signal for axons, and we have shown that Sema3A acts as a repellent guidance cue for migrating progenitor cells and, on prolonged application, induces apoptosis. Both repulsion and induction of cell death are mediated by neuropilin-1, the ligand-binding component of the Sema3A receptor. The vascular endothelial growth factor, VEGF165, antagonizes Sema3A-induced apoptosis and promotes cell survival, migration, and proliferation. Surprisingly, repulsion by Sema3A also depends on expression of VEGFR1, a VEGF165 receptor, expressed in Dev cells. Moreover, we found that these repulsive effects of Sema3A require tyrosine kinase activity, which can be attributed to VEGFR1. These results indicate that the balance between guidance molecules and angiogenic factors can modulate the migration, apoptosis (or survival), and proliferation of neural progenitor cells through shared receptors.
Indexed as
Identifiers
11331362PMC6762465W1927563061What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.