ArticleChromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology2001
Satellite III sequences on 14p and their relevance to Robertsonian translocation formation.
Article in Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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13 citing papers in PubMed, 62 citations in OpenAlex.
- Assessment of Chromosomal Aberrations and S-phase Fraction in Patients With Esophageal Cancer.Cureus · 2025Article
- Mortality and Cancer Incidence in Carriers of Balanced Robertsonian Translocations: A National Cohort Study.American journal of epidemiology · 2019Article
- Implication of LRRC4C and DPP6 in neurodevelopmental disorders.American journal of medical genetics. Part A · 2017Article
- Robertsonian translocations: an overview of 872 Robertsonian translocations identified in a diagnostic laboratory in China.PloS one · 2015Article
- Article
- Narrowing the localization of the region breakpoint in most frequent Robertsonian translocations.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2014Article
- Review
- Article
- Evolution of the structure and composition of house mouse satellite DNA sequences in the subgenus Mus (Rodentia: Muridea): a cytogenomic approach.Chromosoma · 2013Article
- The evolution of African great ape subtelomeric heterochromatin and the fusion of human chromosome 2.Genome research · 2012Article
- Robertsonian fusions, pericentromeric repeat organization and evolution: a case study within a highly polymorphic rodent species, Gerbillus nigeriae.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2010Article
- Genome architecture catalyzes nonrecurrent chromosomal rearrangements.American journal of human genetics · 2003Article
- Parental origin and timing of de novo Robertsonian translocation formation.American journal of human genetics · 2002Review
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Robertsonian translocations (ROBs) are the most common rearrangements in humans, contributing significantly to genetic imbalance, fetal wastage, mental retardation and birth defects. Rob(14q21q) and rob(13q14q), which are formed predominantly during female meiosis, comprise the majority (approximately 85%) of all ROBs. Previous studies have shown that the breakpoints are consistently located within specific regions of the proximal short arms of chromosomes 13, 14, and 21. The high prevalence of these translocations, the consistent breakpoints found, and the fact that roughly 50% of cases occur sporadically suggest that the sequences at or near the breakpoints confer susceptibility to chromosome rearrangement and that the rearrangements occur through a specific mechanism. To investigate this hypothesis, we developed hamster-human somatic cell hybrids derived from de novo rob(14q21q) patients that contained the translocated chromosome segregated from the other acrocentric chromosomes. We determined the physical order of five satellite III subfamilies on 14p, and investigated their involvement in formation of these de novo translocations.
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