ReviewMolecular neurobiology
The cerebral proteopathies: neurodegenerative disorders of protein conformation and assembly.
Review in Molecular neurobiology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
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Who cites it
26 citing papers in PubMed.
- From seeds to symptoms: the molecular landscape of tau seeding in Alzheimer's disease.Frontiers in neuroscience · 2026Review
- PI31 expression is neuroprotective in a mouse model of early-onset parkinsonism.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Effects of Heparan Sulfate Trisaccharide Containing Oleanolic Acid in Attenuating Hyperphosphorylated Tau-Induced Cell Dysfunction Associated with Alzheimer's Disease.Journal of medicinal chemistry · 2025Article
- Hyperphosphorylated Tau Inflicts Intracellular Stress Responses that Are Mitigated by Apomorphine.Molecular neurobiology · 2024Article
- Lipid Homeostasis and Its Links With Protein Misfolding Diseases.Frontiers in molecular neuroscience · 2022Review
- Curcumin as Scaffold for Drug Discovery against Neurodegenerative Diseases.Biomedicines · 2021Review
- Emerging New Concepts of Degrader Technologies.Trends in pharmacological sciences · 2020Review
- The impact of proteostasis dysfunction secondary to environmental and genetic causes on neurodegenerative diseases progression and potential therapeutic intervention.Environmental science and pollution research international · 2020Review
- Aim for the core: suitability of the ubiquitin-independent 20S proteasome as a drug target in neurodegeneration.Translational research : the journal of laboratory and clinical medicine · 2018Review
- Mathematical Modeling of Protein Misfolding Mechanisms in Neurological Diseases: A Historical Overview.Frontiers in neurology · 2018Review
- Prion-like mechanisms in Alzheimer disease.Handbook of clinical neurology · 2018Review
- Resveratrol as a Natural Autophagy Regulator for Prevention and Treatment of Alzheimer's Disease.Nutrients · 2017Review
- Alzheimer's Disease: The Role of Microglia in Brain Homeostasis and Proteopathy.Frontiers in neuroscience · 2017Review
- Role of Neuroinflammation in Amyotrophic Lateral Sclerosis: Cellular Mechanisms and Therapeutic Implications.Frontiers in immunology · 2017Review
- Astrocytes Surviving Severe Stress Can Still Protect Neighboring Neurons from Proteotoxic Injury.Molecular neurobiology · 2016Article
- Protein recycling pathways in neurodegenerative diseases.Alzheimer's research & therapy · 2014Review
- Adaptation and sensitization to proteotoxic stress.Dose-response : a publication of International Hormesis Society · 2014Article
- Targeting heat shock proteins to modulate α-synuclein toxicity.Therapeutic advances in neurological disorders · 2014Review
- Neocortex and allocortex respond differentially to cellular stress in vitro and aging in vivo.PloS one · 2013Article
- Corruption and spread of pathogenic proteins in neurodegenerative diseases.The Journal of biological chemistry · 2012Review
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The abnormal assembly and deposition of specific proteins in the brain is the probable cause of most neurodegenerative disease afflicting the elderly. These "cerebral proteopathies" include Alzheimer's disease (AD), Parkinson's disease (PD), Huntington's disease (HD), prion diseases, and a variety of other disorders. Evidence is accumulating that the anomalous aggregation of the proteins, and not a loss of protein function, is central to the pathogenesis of these diseases. Thus, therapeutic strategies that reduce the production, accumulation, or polymerization of pathogenic proteins might be applicable to a wide range of some of the most devastating diseases of old age.
Indexed as
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.