ReviewMolecular neurobiology
Opioid tolerance and the emergence of new opioid receptor-coupled signaling.
Review in Molecular neurobiology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 65 citations in OpenAlex.
- Disulfiram Abrogates Morphine Tolerance-A Possible Role of µ-Opioid Receptor-Related G-Protein Activation in the Striatum.International journal of molecular sciences · 2021Article
- Pharmacological Chaperones Attenuate the Development of Opioid Tolerance.International journal of molecular sciences · 2020Article
- Phosphorylation of unique C-terminal sites of the mu-opioid receptor variants 1B2 and 1C1 influences their Gs association following chronic morphine.Journal of neurochemistry · 2020Article
- Retracted Article: Upregulation of miR-26b alleviates morphine tolerance by inhibiting BDNFRSC advances · 2019Article
- A Differential Hypofunctionality of Gαi Proteins Occurs in Adolescent Idiopathic Scoliosis and Correlates with the Risk of Disease Progression.Scientific reports · 2019Article
- Opioids Resistance in Chronic Pain Management.Current neuropharmacology · 2017Review
- miR-365 targets β-arrestin 2 to reverse morphine tolerance in rats.Scientific reports · 2016Article
- Contribution of adrenomedullin to the switch of G protein-coupled μ-opioid receptors from Gi to Gs in the spinal dorsal horn following chronic morphine exposure in rats.British journal of pharmacology · 2016Article
- Ligand-specific regulation of the endogenous mu-opioid receptor by chronic treatment with mu-opioid peptide agonists.BioMed research international · 2013Article
- A novel alternatively spliced isoform of the mu-opioid receptor: functional antagonism.Molecular pain · 2010Article
- Supraspinal Gbetagamma-dependent stimulation of PLCbeta originating from G inhibitory protein-mu opioid receptor-coupling is necessary for morphine induced acute hyperalgesia.Journal of neurochemistry · 2009Article
- Mu-opioid receptor redistribution in the locus coeruleus upon precipitation of withdrawal in opiate-dependent rats.Anatomical record (Hoboken, N.J. : 2007) · 2009Article
- Characterizing intercellular signaling peptides in drug addiction.Neuropharmacology · 2009Review
- Morphine induces ubiquitin-proteasome activity and glutamate transporter degradation.The Journal of biological chemistry · 2008Article
- Oxycodone plus ultra-low-dose naltrexone attenuates neuropathic pain and associated mu-opioid receptor-Gs coupling.The journal of pain · 2008Article
- High-affinity naloxone binding to filamin a prevents mu opioid receptor-Gs coupling underlying opioid tolerance and dependence.PloS one · 2008Article
- Expression of spinal NMDA receptor and PKCgamma after chronic morphine is regulated by spinal glucocorticoid receptor.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2005Article
- G-protein receptor kinase 3 (GRK3) influences opioid analgesic tolerance but not opioid withdrawal.British journal of pharmacology · 2004Article
- Reciprocal modulation of phospholipase Cbeta isoforms: adaptation to chronic morphine.Proceedings of the National Academy of Sciences of the United States of America · 2003Article
- The neurobiology of opiate tolerance, dependence and sensitization: mechanisms of NMDA receptor-dependent synaptic plasticity.Neurotoxicity research · 2002Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Multiple cellular adaptations are elicited by chronic exposure to opioids. These include diminution of spare opioid receptors, decreased opioid receptor density, and G-protein content and coupling thereof. All imply that opioid tolefance is a manifestation of a loss of opioid function, i.e., desensitization. Recent observations challenge the exclusiveness of this formulation and indicate that opioid tolerance also results from qualitative changes in opioid signaling. In this article, Gintzler and Chakrabarti discuss the evidence that suggests that opioid tolerance results not only from impaired opioid receptor functionality, but also from altered consequences of coupling. Underlying the latter are fundamental changes in the nature of effectors that are coupled to the opioid receptor/G-protein signaling pathway. These molecular changes include the upregulation of adenylyl cyclase isoforms of the type II family as well as a substantial increase in their phosphorylation state. As a result, there is a shift in opioid receptor/G-protein signaling from predominantly Gialpha inhibitory to Gbetagamma stimulatory following chronic in vivo morphine exposure. These adaptations to chronic morphine indicate the plasticity of opioid-signal transduction mechanisms and the ability of chronic morphine to augment new signaling strategies.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.