ArticleNeoplasia (New York, N.Y.)
Evidence of chromosomal instability in prostate cancer determined by spectral karyotyping (SKY) and interphase fish analysis.
Article in Neoplasia (New York, N.Y.). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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25 citing papers in PubMed, 54 citations in OpenAlex.
- Genomic analyses of the metastasis-derived prostate cancer cell lines LNCaP, VCaP, and PC3-AR.The Prostate · 2022Article
- ATP-binding cassette transporters mediate differential biosynthesis of glycosphingolipid species.Journal of lipid research · 2021Article
- Evaluation of Plasma Circulating Cell Free DNA Concentration and Integrity in Patients with Prostate Cancer in Jamaica: A Preliminary Study.Diseases (Basel, Switzerland) · 2020Article
- Rapamycin treatment correlates changes in primary cilia expression with cell cycle regulation in epithelial cells.Biochemical pharmacology · 2020Article
- Article
- Single nucleotide variations in cultured cancer cells: Effect of mismatch repair.Mutation research · 2017Article
- Visualizing chromosome segregation in live cells.Cell cycle (Georgetown, Tex.) · 2016Article
- Mutational Landscape of Aggressive Prostate Tumors in African American Men.Cancer research · 2016Article
- Cancerous inhibitor of protein phosphatase 2A promotes premature chromosome segregation and aneuploidy in prostate cancer cells through association with shugoshin.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2015Article
- Plumbagin elicits differential proteomic responses mainly involving cell cycle, apoptosis, autophagy, and epithelial-to-mesenchymal transition pathways in human prostate cancer PC-3 and DU145 cells.Drug design, development and therapy · 2015Article
- A novel multiplexed, image-based approach to detect phenotypes that underlie chromosome instability in human cells.PloS one · 2015Article
- The detection and implication of genome instability in cancer.Cancer metastasis reviews · 2013Review
- Article
- Male germ cell-associated kinase is overexpressed in prostate cancer cells and causes mitotic defects via deregulation of APC/CCDH1.Oncogene · 2012Article
- The APC/C Ubiquitin Ligase: From Cell Biology to Tumorigenesis.Frontiers in oncology · 2011Article
- The molecular basis of genistein-induced mitotic arrest and exit of self-renewal in embryonal carcinoma and primary cancer cell lines.BMC medical genomics · 2008Article
- Cytogenetically balanced translocations are associated with focal copy number alterations.Human genetics · 2007Article
- Mutational targets in colorectal cancer cells with microsatellite instability.Familial cancer · 2006Review
- Article
- U94 alters FN1 and ANGPTL4 gene expression and inhibits tumorigenesis of prostate cancer cell line PC3.Cancer cell international · 2005Article
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The way in which cytogenetic aberrations develop in prostate cancer (CaP) is poorly understood. Spectral karyotype (SKY) analysis of CaP cell lines has shown that they have unstable karyotypes and also have features associated with chromosomal instability (CIN). To accurately determine the incidence of de novo structural and numerical aberrations in vitro in CaP, we performed SKY analysis of three independent clones derived from one representative cell line, DU145. The frequent generation of new chromosomal rearrangements and a wide variation in the number of structural aberrations within two to five passages suggested that this cell line exhibited some of the features associated with a CIN phenotype. To study numerical cell-to-cell variation, chromosome 8 aneusomy was assessed in the LNCaP, DU145, and PC-3 cell lines and a patient cohort of 15 CaP primary tumors by interphase fluorescence in situ hybridization (FISH). This analysis showed that a high frequency of numerical alteration affecting chromosome 8 was present in both in vitro and in CaP tissues. In comparison to normal controls, the patient cohort had a statistically significant (P<.05), greater frequency of cells with one and three centromere 8 copies. These data suggest that a CIN-like process may be contributing towards the generation of de novo numerical and structural chromosome abnormalities in CaP.
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