ArticleMolecular psychiatry2001
Attention-deficit hyperactivity disorder and the adrenergic receptors alpha 1C and alpha 2C.
Article in Molecular psychiatry, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
7 citing papers in PubMed, 42 citations in OpenAlex.
- Attention-deficit/hyperactive disorder updates.Frontiers in molecular neuroscience · 2022Review
- Effects of atomoxetine on hyper-locomotive activity of the prenatally valproate-exposed rat offspring.Biomolecules & therapeutics · 2014Article
- Molecular genetics of attention deficit hyperactivity disorder.The Psychiatric clinics of North America · 2010Review
- Association of ADHD and the Protogenin gene in the chromosome 15q21.3 reading disabilities linkage region.Genes, brain, and behavior · 2008Article
- Norepinephrine transporter and catecholamine-O-methyltransferase gene variants and attention-deficit/hyperactivity disorder symptoms in adults.Journal of neural transmission (Vienna, Austria : 1996) · 2008Article
- [Attention deficit hyperactivity disorder in adults. An overview].Der Nervenarzt · 2004Article
- A genomewide scan for attention-deficit/hyperactivity disorder in an extended sample: suggestive linkage on 17p11.American journal of human genetics · 2003Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
Abstract
The adrenergic system has been hypothesized to be involved in the etiology of attention-deficit hyperactivity disorder (ADHD) based on pharmacological interventions and animal models. Noradrenergic neurons are implicated in the modulation of vigilance, improvement of visual attention, initiation of adaptive response, learning and memory. In this study we tested the genes for two adrenergic receptors, alpha 1C (ADRA1C) located on chromosome 8p11.2, and alpha 2C (ADRA2C) located on chromosome 4p16, as genetic susceptibility factors in ADHD. For the adrenergic receptor alpha 1C we used a C to T polymorphism that results in a change of Cys to Arg at codon 492 for the linkage study. For the adrenergic receptor alpha 2C gene we examined a dinucleotide repeat polymorphism located approximately 6 kb from the gene. We examined these polymorphisms in a sample of 103 families ascertained through an ADHD proband. Using the transmission disequilibrium test, we did not observe biased transmission of any of the alleles of these polymorphisms. We conclude that the alleles at the polymorphisms tested in these two genes are not linked to the ADHD phenotype in this sample of families.
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Registered trials
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