ArticleBritish journal of pharmacology2001
Histamine H(3) receptor-mediated inhibition of depolarization-induced, dopamine D(1) receptor-dependent release of [(3)H]-gamma-aminobutryic acid from rat striatal slices.
Article in British journal of pharmacology, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed, 85 citations in OpenAlex.
- The Interaction of Histamine HPharmaceuticals (Basel, Switzerland) · 2024Review
- Histamine HBiomolecules · 2024Review
- Chronic HPsychopharmacology · 2023Article
- Histamine HCellular and molecular neurobiology · 2022Article
- Therapeutic Potential of Histamine H3 Receptors in Substance Use Disorders.Current topics in behavioral neurosciences · 2022Review
- Role of the Dopaminergic System in the Striatum and Its Association With Functional Recovery or Rehabilitation After Brain Injury.Frontiers in neuroscience · 2021Review
- Mechanism of Action of Atypical Antipsychotic Drugs in Mood Disorders.International journal of molecular sciences · 2020Review
- Histaminergic Control of Corticostriatal Synaptic Plasticity during Early Postnatal Development.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Chronic administration of the histamine HPsychopharmacology · 2019Article
- Adenosine APurinergic signalling · 2019Article
- Functional histamine HPharmacological research · 2018Article
- The histamine H3 receptor antagonist thioperamide rescues circadian rhythm and memory function in experimental parkinsonism.Translational psychiatry · 2017Article
- Histamine and the striatum.Neuropharmacology · 2016Review
- International Union of Basic and Clinical Pharmacology. XCVIII. Histamine Receptors.Pharmacological reviews · 2015Review
- Histamine H3 receptor activation counteracts adenosine A2A receptor-mediated enhancement of depolarization-evoked [3H]-GABA release from rat globus pallidus synaptosomes.ACS chemical neuroscience · 2014Article
- Procognitive properties of drugs with single and multitargeting H3 receptor antagonist activities.CNS neuroscience & therapeutics · 2014Review
- Cocaine disrupts histamine H3 receptor modulation of dopamine D1 receptor signaling: σ1-D1-H3 receptor complexes as key targets for reducing cocaine's effects.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- Histamine H₃ receptors, the complex interaction with dopamine and its implications for addiction.British journal of pharmacology · 2013Review
- The histaminergic network in the brain: basic organization and role in disease.Nature reviews. Neuroscience · 2013Review
- Mechanisms underlying the onset and expression of levodopa-induced dyskinesia and their pharmacological manipulation.Journal of neural transmission (Vienna, Austria : 1996) · 2011Review
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
1. A study was made of the regulation of [(3)H]-gamma-aminobutyric acid ([(3)H]-GABA) release from slices of rat striatum by endogenous dopamine and exogenous histamine and a histamine H(3)-agonist. Depolarization-induced release of [(3)H]-GABA was Ca(2+)-dependent and was increased in the presence of the dopamine D(2) receptor family antagonist, sulpiride (10 microM). The sulpiride-potentiated release of [(3)H]-GABA was strongly inhibited by the dopamine D(1) receptor family antagonist, SCH 23390 (1 microM). Neither antagonist altered basal release. 2. The 15 mM K(+)-induced release of [(3)H]-GABA in the presence of sulpiride was inhibited by 100 microM histamine (mean inhibition 78+/-3%) and by the histamine H(3) receptor-selective agonist, immepip, 1 microM (mean inhibition 81+/-5%). The IC(50) values for histamine and immepip were 1.3+/-0.2 microM and 16+/-2 nM, respectively. The inhibitory effects of histamine and immepip were reversed by the H(3) receptor antagonist, thioperamide, 1 microM. 3. The inhibition of 15 mM K(+)-induced [(3)H]-GABA release by immepip was reversed by the H(3) receptor antagonist, clobenpropit, K(d) 0.11+/-0.04 nM. Clobenpropit alone had no effect on basal or stimulated release of [(3)H]-GABA. 4. Elevated K(+) caused little release of [(3)H]-GABA from striatal slices from reserpinized rats, unless the D(1) partial agonist, R(+)-SKF 38393, 1 microM, was also present. The stimulated release in the presence of SKF 38393 was reduced by 1 microM immepip to the level obtained in the absence of SKF 38393. 5. These observations demonstrate that histamine H(3) receptor activation strongly inhibits the dopamine D(1) receptor-dependent release of [(3)H]-GABA from rat striatum; primarily through an interaction at the terminals of GABA neurones.
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