ArticleVirus genes2001
Comparison of the 5' leader sequences of North American isolates of reference and field strains of porcine reproductive and respiratory syndrome virus (PRRSV).
Article in Virus genes, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 19 citations in OpenAlex.
- Development of GFP-expressing infectious clones for PRRSV using TAR cloning for antiviral drug screening.Npj viruses · 2025Article
- Article
- Role of transcription regulatory sequence in regulation of gene expression and replication of porcine reproductive and respiratory syndrome virus.Veterinary research · 2017Article
- PRRSV structure, replication and recombination: Origin of phenotype and genotype diversity.Virology · 2015Review
- A novel isolate with deletion in GP3 gene of porcine reproductive and respiratory syndrome virus from mid-eastern China.BioMed research international · 2014Article
- A 5'-proximal stem-loop structure of 5' untranslated region of porcine reproductive and respiratory syndrome virus genome is key for virus replication.Virology journal · 2011Article
- Peptide-conjugated morpholino oligomers inhibit porcine reproductive and respiratory syndrome virus replication.Antiviral research · 2008Article
- CD163 expression confers susceptibility to porcine reproductive and respiratory syndrome viruses.Journal of virology · 2007Article
- Suppression of porcine reproductive and respiratory syndrome virus replication by morpholino antisense oligomers.Veterinary microbiology · 2006Article
- Molecular characterization of PL97-1, the first Korean isolate of the porcine reproductive and respiratory syndrome virus.Virus research · 2004Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The 5' leader is documented to be an important regulatory element in many (+) ssRNAvirus genome. To understand the significance of the 5' leader RNA of PRRSV, we determined the complete leader sequences of fifteen different North American strains of PRRSV and predicted their secondary structures. Viruses analysed included three reference strains and nine field strains originating from different geographic locations. To further examine the leader region, one of the field strains was adapted to grow in tissue culture, and three clones were isolated. We also predicted the secondary structures of two European strains based on their published sequences. The predicted RNA secondary structures of the leader sequences suggested the existence of three conserved domains formed by the 5' region of the leader among the North American strains, two of which were conserved in the European strains. A variable structural domain was predicted from the 3' region of the leader sequences of the North American strains, where all tissue culture-adapted isolates were characterized by a stem-loop while field isolates were characterized by an internal bulge within the stem-loop.
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