ArticleAnnals of surgery2001
Enteral nutrition prevents remote organ injury and death after a gut ischemic insult.
Article in Annals of surgery, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 72 citations in OpenAlex.
- Gastric emptying in mechanically ventilated critically ill patients: effect of neuromuscular blocking agent.Intensive care medicine · 2003Trial
- Nutritional Intake in Children with Septic Shock: A Retrospective Single-Center Study.Journal of pediatric intensive care · 2024Article
- Nutritional Support in Children Meeting the At-Risk for Pediatric Acute Respiratory Distress Syndrome Criteria.Critical care explorations · 2023Article
- What do we know about optimal nutritional strategies in children with pediatric acute respiratory distress syndrome?Annals of translational medicine · 2019Review
- Pediatric Multiple Organ Dysfunction Syndrome: Promising Therapies.Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies · 2017Review
- Gastrointestinal immune and microbiome changes during parenteral nutrition.American journal of physiology. Gastrointestinal and liver physiology · 2017Review
- Nutrition: A Primary Therapy in Pediatric Acute Respiratory Distress Syndrome.Frontiers in pediatrics · 2016Review
- Route and type of nutrition and surgical stress influence secretory phospholipase A2 secretion of the murine small intestine.JPEN. Journal of parenteral and enteral nutrition · 2011Article
- Nutrition and gut immunity.The Surgical clinics of North America · 2011Review
- Parenteral nutrition impairs lymphotoxin β receptor signaling via NF-κB.Annals of surgery · 2011Article
- Commensal microflora induce host defense and decrease bacterial translocation in burn mice through toll-like receptor 4.Journal of biomedical science · 2010Article
- Parenteral nutrition maintains pulmonary IgA antibody transport capacity, but not active transport, following injury.American journal of surgery · 2009Article
- Food fight! Parenteral nutrition, enteral stimulation and gut-derived mucosal immunity.Langenbeck's archives of surgery · 2009Review
- Ischemia-reperfusion injury of the intestine and protective strategies against injury.Digestive diseases and sciences · 2004Review
- Improvements of postburn renal function by early enteral feeding and their possible mechanisms in rats.World journal of gastroenterology · 2003Article
- Protective effects of medium-chain triglycerides on the liver and gut in rats administered endotoxin.Annals of surgery · 2003Article
- Jonathan E Rhoads lecture: Of mice and men... and a few hundred rats.JPEN. Journal of parenteral and enteral nutritionArticle
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
objectiveTo determine whether parenteral feeding (IV-TPN) influences the local and systemic response to an intestinal insult. SUMMARY BACKGROUND DATA: Parenteral feeding increases ICAM-1 expression and attracts neutrophils (PMNs) to the intestine compared with enterally fed animals. Because the gut is a priming bed for PMNs, the authors hypothesized that IV-TPN may affect organ injury after gut ischemia-reperfusion (I/R).
methodsMice were randomized to chow, IV-TPN, intragastric TPN, or complex enteral diet for 5 days' feeding. In experiment 1, 162 mice underwent 15 or 30 minutes of gut I/R, and death was recorded at 72 hours. In experiment 2, 43 mice underwent 15 minutes of gut ischemia and permeability was measured by 125I-labeled albumin at 3 hours after reperfusion. Lung PMN accumulation was measured by myeloperoxidase assay. In experiment 3, albumin leak was tested in the complex enteral diet group (n = 5) and the intragastric TPN group (n = 5) after 30 minutes of gut ischemia and 1 hour of reperfusion.
resultsIn experiment 1, enteral feeding significantly reduced the death rate compared with IV-TPN after 15 minutes of I/R. After 30 minutes of gut ischemia, the IV-TPN and intragastric TPN groups showed a higher death rate than the chow and enteral diet groups. In experiment 2, IV-TPN significantly increased pulmonary and hepatic 125I albumin leak compared with enteral feeding without increasing pulmonary myeloperoxidase levels. In experiment 3, there were no differences in 125I albumin leak between the complex enteral diet and intragastric TPN groups.
conclusionEnteral feeding reduced the death rate and organ permeability after 15 minutes of ischemia. However, prolonged ischemia (30 minutes) eliminated any benefits of intragastric TPN on survival.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.