ArticleMolecular pathology : MP2001
Activity of the EBNA1 promoter associated with lytic replication (Fp) in Epstein-Barr virus associated disorders.
Article in Molecular pathology : MP, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Review
- Remodeling of the ribosomal quality control and integrated stress response by viral ubiquitin deconjugases.Nature communications · 2023Article
- Article
- Prevalence of Epstein-Barr virus infection and characteristics of lymphocyte subsets in newly onset juvenile dermatomyositis.World journal of pediatrics : WJP · 2021Article
- Prevalence of Epstein–Barr Virus Genotypes in Pakistani Lymphoma PatientsAsian Pacific journal of cancer prevention : APJCP · 2018Article
- Epigenetic Impact on EBV Associated B-Cell Lymphomagenesis.Biomolecules · 2016Review
- Functional analysis and molecular characterization of spontaneously outgrown human lymphoblastoid cell lines.Molecular biology reports · 2014Article
- Therapeutic vaccination against the rhesus lymphocryptovirus EBNA-1 homologue, rhEBNA-1, elicits T cell responses to novel epitopes in rhesus macaques.Journal of virology · 2013Article
- Functions of the Epstein-Barr virus EBNA1 protein in viral reactivation and lytic infection.Journal of virology · 2012Article
- The Epstein-Barr Virus EBNA1 Protein.Scientifica · 2012Review
- Conserved mutation of Epstein-Barr virus-encoded BamHI-A Rightward Frame-1 (BARF1) gene in Indonesian nasopharyngeal carcinoma.Infectious agents and cancer · 2010Article
- Review
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Authors and funding
5 authors.
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No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND/
aimsIn Epstein-Barr virus (EBV) positive cell lines that are stably infected, three different promoters are known to direct the transcription of EBV nuclear antigen 1 (EBNA1). These are located in the BamHI-C, BamHI-Q, and BamHI-F regions of the viral genome (Cp, Qp, and Fp, respectively). Fp is activated upon induction of the viral lytic cycle. The aim of this study was to investigate the activity of Fp in EBV associated diseases.
methodsUsing reverse transcriptase polymerase chain reaction, a qualitative analysis of EBNA1 promoter usage in various EBV associated diseases was performed.
resultsFp driven transcription was detected in the context of primary infection and/or lytic replication; at least a portion of the Fp driven transcripts encoded EBNA1. Qp driven EBNA1 transcripts were detected in most samples across the range of disorders tested. Cp driven EBNA1 transcripts were detected in the context of immune suppression and in samples containing EBV positive (non-neoplastic) lymphoid cells.
conclusionsThese results confirm the previously proposed "housekeeping" function of the Qp promoter.
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