ArticleMolecular pathology : MP2001
Disparate E-cadherin mutations in LCIS and associated invasive breast carcinomas.
Article in Molecular pathology : MP, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 45 citations in OpenAlex.
- High-Throughput Sequencing Identifies 3 Novel Susceptibility Genes for Hereditary Melanoma.Genes · 2020Article
- Molecular Classification of Lobular Carcinoma of the Breast.Scientific reports · 2017Article
- Snail1 expression in human colon cancer DLD-1 cells confers invasive properties without N-cadherin expression.Biochemistry and biophysics reports · 2016Article
- Targeted capture massively parallel sequencing analysis of LCIS and invasive lobular cancer: Repertoire of somatic genetic alterations and clonal relationships.Molecular oncology · 2016Article
- Molecular drivers of lobular carcinoma in situ.Breast cancer research : BCR · 2015Review
- SMAD4 regulates cell motility through transcription of N-cadherin in human pancreatic ductal epithelium.PloS one · 2014Article
- Clonal relatedness between lobular carcinoma in situ and synchronous malignant lesions.Breast cancer research : BCR · 2012Article
- Cadherin-catenin complex dissociation in lobular neoplasia of the breast.Breast cancer research and treatment · 2012Article
- DNA hypermethylation and clinicopathological features in breast cancer: the Western New York Exposures and Breast Cancer (WEB) Study.Breast cancer research and treatment · 2009Article
- Non-operative breast pathology: lobular neoplasia.Journal of clinical pathology · 2007Review
- Precursors and preinvasive lesions of the breast: the role of molecular prognostic markers in the diagnostic and therapeutic dilemma.World journal of surgical oncology · 2007Review
- Article
- Somatic sequence alterations in twenty-one genes selected by expression profile analysis of breast carcinomas.Breast cancer research : BCR · 2007Article
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimsThe relation between lobular carcinoma in situ (LCIS) and invasive breast cancer is unresolved. In an attempt to establish whether LCIS is a precursor of invasive cancer the mutational status and the expression of E-cadherin was analysed in LCIS and associated invasive breast carcinoma in 23 patients.
methodsFoci of LCIS and associated invasive carcinoma were individually microdissected from tissue from 23 patients. Exons 4-16 of the E-cadherin gene were analysed using single strand conformation polymorphism (SSCP); protein expression and the localisation of E-cadherin and beta-catenin were assessed with the use of immunohistochemistry.
resultsImmunohistochemistry revealed a lack of expression of E-cadherin and beta-catenin in most LCIS samples and invasive foci. In all but four cases, the staining pattern was identical in the LCIS and associated invasive areas. When E-cadherin was absent, beta-catenin was also undetected, suggesting a lack of expression of alternative classic cadherin members in these lesions. Coincident E-cadherin mutations in LCIS and associated invasive carcinoma were not identified in this series of patients. However, mutational analysis of E-cadherin in multiple foci of carcinoma in situ surrounding an invasive lesion provided evidence to support ductal carcinoma in situ as a precursor of invasive ductal carcinoma.
conclusionThese data support the hypothesis that LCIS is not a precursor of invasive breast carcinoma but a marker of increased risk of developing invasive disease.
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