ArticleJournal of clinical immunology2001
BCG infection in allergen-presensitized rats suppresses Th2 immune response and prevents the development of allergic asthmatic reaction.
Article in Journal of clinical immunology, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 35 citations in OpenAlex.
- InactivatedIranian journal of basic medical sciences · 2016Article
- The effect of natural adjuvants on pathological changes in sensitized Guinea pig lungs.Iranian Red Crescent medical journal · 2014Article
- Therapeutic effects of mycobacterial secretory proteins against established asthma in BALB/c mice.Allergy, asthma & immunology research · 2012Article
- The antiasthma effect of neonatal BCG vaccination does not depend on the Th17/Th1 but IL-17/IFN-γ balance in a BALB/c mouse asthma model.Journal of clinical immunology · 2011Article
- Preventive effects of mycobacteria and their culture supernatants against asthma development in BALB/c mice.Allergy, asthma & immunology research · 2010Article
- Suppression of allergic airway inflammation in a mouse model by Der p2 recombined BCG.Immunology · 2009Article
- Ag85B DNA vaccine suppresses airway inflammation in a murine model of asthma.Respiratory research · 2009Article
- Pathogen induced regulatory cell populations preventing allergy through the Th1/Th2 paradigm point of view.Immunologic research · 2008Review
- Dishing the dirt on asthma: What we can learn from poor hygiene.Biologics : targets & therapy · 2007Article
- Effects of cytokine milieu secreted by BCG-treated dendritic cells on allergen-specific Th immune response.Journal of Korean medical science · 2004Article
- Health impacts of environmental mycobacteria.Clinical microbiology reviews · 2004Review
- Interferon-alpha/beta receptor-mediated selective induction of a gene cluster by CpG oligodeoxynucleotide 2006.BMC immunology · 2003Article
- Effects of respiratory Mycoplasma pneumoniae infection on allergen-induced bronchial hyperresponsiveness and lung inflammation in mice.Infection and immunity · 2003Article
- Environmental contributions to the allergic asthma epidemic.Environmental health perspectives · 2002Review
- Cell cooperation in development of eosinophil-predominant inflammation in airways.Immunologic research · 2002Review
- Effects of BCG infection on Schultz-Dale reaction, allergen-specific IgE levels, and Th2 immune response in sensitized rats.The Korean journal of internal medicine · 2001Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Recent investigations demonstrate that bacille Calmette-Guerin (BCG), a potent inducer of Th1 response, infection prior to allergen sensitization inhibits Th2 immune responses to the allergen. However, it is not clear whether BCG infection in allergen-presensitized rats switches off Th2 response and prevents allergic asthmatic reaction to the subsequent allergen exposure. In this study we investigate whether BCG infection in ovalbumin (OVA)-presensitized Sprague-Dawley rats suppresses airway hyperresponsiveness and eosinophilic inflammation induced by OVA and Th2 cytokine production. BCG infection in OVA-presensitized rats significantly inhibited not only the sensitivity of airway smooth muscle to electrical field stimulation and acetylcholine but also absolute eosinophil counts in bronchoalveolar lavage fluid. As a correlate, interleukin-4 (IL-4) production significantly decreased and interferon-gamma (IFN-gamma) slightly increased, resulting in a markedly decreased ratio of IL-4-IFN-gamma in OVA-presensitized rats with BCG infection. These results indicate that BCG infection in pre-sensitized rats suppresses allergic asthmatic reaction and Th2 immune response. It is possible from these findings that BCG vaccine may be used as an immunomodulating agent for the sensitized host with preestablished Th2 memory.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.