Evidence map›Paper›PMID 11321232›Full record

ReviewJournal of clinical immunology2001

The Fas signaling connection between autoimmunity and embryonic lethality.

H C Hsu, Y Matsuki, H G Zhang, T Zhou, J D Mountz

Abstract readReview
PubMed Publisher
In one paragraph

Review in Journal of clinical immunology, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 49% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 6 citations in OpenAlex.

  1. Monogenic disorders of the TNF signalling pathway.Nature reviews. Rheumatology · 2026
    Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

H C HsuDepartment of Medicine, University of Alabama at Birmingham, 35294, USA.
Y Matsuki
H G Zhang
T Zhou
J D Mountz
University of Alabama at Birmingham · US

Funding

IN VIVO IMAGE ANALYSIS OF AUTOREACTIVE T CELLSR01AI046990 · NIAID · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI MOUNTZ, JOHN D · 1999 to 2003
$2.0M
B CELL DEFICIENCY IN A/WYSNJ MICER01AI042990 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI CANCRO, MICHAEL PAUL · 1998 to 2001
$524k
GENE THERAPY TO CORRECT ARTHRITIS IN AUTOIMMUNE MICEN01AR062224 · NIAMS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI MOUNTZ, JOHN D · 1996 to 2000
$328k
NIAID NIH HHS R01-AI-42990NIAID NIH HHS R01-AI-46990NIAMS NIH HHS N0-1 AR-62224
6 · The paper itself

Abstract

The first gene to cause systemic autoimmune disease in mice was identified as the fas gene, which is mutated in lymphoproliferative (lpr) mice. These mice exhibited a defect in activation-inducted cell death of T cells and B cells in vivo, causing a failure of proper clearance of immune cells and defective down-modulation of an immune response. This led to the speculation that apoptosis defects may play a role in defective down-modulation of the hyperimmune response observed in human autoimmune diseases. More recently, scientists have generated different mouse lines with defects in Fas-apoptosis-associated molecules such as FADD and Apaf-1. These mice, however, died during embryonic development and did not develop autoimmune disease. These findings suggest that molecules associated with Fas apoptosis signaling can be important at the most limited levels for development of the immune system but also have more global apoptosis roles in other systems. We propose that the more global role of Fas-associated apoptosis molecules should be considered when evaluating their role in autoimmune disease.

Indexed as

ApoptosisArabidopsis ProteinsAnimalsApoptotic Protease-Activating Factor 1Autoimmune DiseasesEmbryo LossFas Ligand ProteinFatty Acid DesaturasesHumansImmune SystemIntracellular Signaling Peptides and ProteinsMembrane GlycoproteinsMiceProteinsProtein Tyrosine Phosphatase, Non-Receptor Type 6Protein Tyrosine PhosphatasesAPAF1 protein, humanApaf1 protein, mouseApoptotic Protease-Activating Factor 1Arabidopsis ProteinsFad7 protein, ArabidopsisFASLG protein, humanFas Ligand ProteinFasl protein, mouseFatty Acid DesaturasesIntracellular Signaling Peptides and ProteinsMembrane GlycoproteinsProteinsProtein Tyrosine Phosphatase, Non-Receptor Type 6Protein Tyrosine PhosphatasesPTPN6 protein, humanPtpn6 protein, mouseReceptors, Antigen, T-Cell

Identifiers

PMID11321232
OpenAlexW50353502

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.