ArticleProceedings of the National Academy of Sciences of the United States of America2001
Growth factors regulate phototransduction in retinal rods by modulating cyclic nucleotide-gated channels through dephosphorylation of a specific tyrosine residue.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 36 citations in OpenAlex.
- The neurobiology of insulin-like growth factor I: From neuroprotection to modulation of brain states.Molecular psychiatry · 2023Review
- Adaptation memory in photoreceptors: different mechanisms in rods and cones.Frontiers in molecular neuroscience · 2023Article
- Article
- Role of recoverin in rod photoreceptor light adaptation.The Journal of physiology · 2018Article
- Structural Basis for Interactions Between Contactin Family Members and Protein-tyrosine Phosphatase Receptor Type G in Neural Tissues.The Journal of biological chemistry · 2016Article
- Signalling beyond photon absorption: extracellular retinoids and growth factors modulate rod photoreceptor sensitivity.The Journal of physiology · 2016Article
- Adaptive potentiation in rod photoreceptors after light exposure.The Journal of general physiology · 2014Article
- Insulin receptor regulates photoreceptor CNG channel activity.American journal of physiology. Endocrinology and metabolism · 2012Article
- Article
- Tyrosine phosphorylation of cGMP-gated ion channels is under circadian control in chick retina photoreceptors.Investigative ophthalmology & visual science · 2007Article
- Insulin-like growth factor-1 inhibits adult supraoptic neurons via complementary modulation of mechanoreceptors and glycine receptors.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2005Article
- Circadian regulation of cGMP-gated channels of vertebrate cone photoreceptors: role of cAMP and Ras.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2004Article
- Tyrosine phosphorylation of rod cyclic nucleotide-gated channels switches off Ca2+/calmodulin inhibition.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2003Article
- Subunit contributions to phosphorylation-dependent modulation of bovine rod cyclic nucleotide-gated channels.The Journal of physiology · 2003Article
- Brain repair and neuroprotection by serum insulin-like growth factor I.Molecular neurobiology · 2003Review
- Potentiation of 'on' bipolar cell flash responses by dim background light and cGMP in dogfish retinal slices.The Journal of physiology · 2002Article
- Regulated cationic channel function in Xenopus oocytes expressing Drosophila big brain.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2002Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Illumination of vertebrate rod photoreceptors leads to a decrease in the cytoplasmic cGMP concentration and closure of cyclic nucleotide-gated (CNG) channels. Except for Ca(2+), which plays a negative feedback role in adaptation, and 11-cis-retinal, supplied by the retinal pigment epithelium, all of the biochemical machinery of phototransduction is thought to be contained within rod outer segments without involvement of extrinsic regulatory molecules. Here we show that insulin-like growth factor-I (IGF-I), a paracrine factor released from the retinal pigment epithelium, alters phototransduction by rapidly increasing the cGMP sensitivity of CNG channels. The IGF-I-signaling pathway ultimately involves a protein tyrosine phosphatase that catalyzes dephosphorylation of a specific residue in the alpha-subunit of the rod CNG channel protein. IGF-I conjointly accelerates the kinetics and increases the amplitude of the light response, distinct from events that accompany adaptation. These effects of IGF-I could result from the enhancement of the cGMP sensitivity of CNG channels. Hence, in addition to long-term control of development and survival of rods, growth factors regulate phototransduction in the short term by modulating CNG channels.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.