ReviewMolecular psychiatry2001
The search for complex disease genes: fault by linkage or fault by association?
Review in Molecular psychiatry, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
10 citing papers in PubMed, 45 citations in OpenAlex.
- Obsessive-Compulsive Disorder, 5-HTTLPR polymorphism and treatment response.The pharmacogenomics journal · 2002Trial
- The immunogenetics of tuberculosis (TB) susceptibility.Immunogenetics · 2023Review
- Genetics of complex respiratory diseases: implications for pathophysiology and pharmacology studies.British journal of pharmacology · 2011Review
- Association studies of 22 candidate SNPs with late-onset Alzheimer's disease.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics · 2009Article
- Summary of contributions to GAW Group 15: family-based samples are useful in identifying common polymorphisms associated with complex traits.Genetic epidemiology · 2009Article
- Multifactor dimensionality reduction-phenomics: a novel method to capture genetic heterogeneity with use of phenotypic variables.American journal of human genetics · 2007Article
- Genes and human elite athletic performance.Human genetics · 2005Review
- Manic-depression genes and the new millennium: poised for discovery.Molecular psychiatry · 2002Review
- Genetic mechanisms of behavior--don't forget about the transcription factors.Molecular psychiatry · 2001Review
- Genetics of schizophrenia and the new millennium: progress and pitfalls.American journal of human genetics · 2001Review
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
With the human DNA sequence nearing completion, the search for complex disease genes is gaining momentum, as is the debate over gene-finding strategies. This overview contrasts two pivotal methods: linkage analysis and association mapping. Linkage analysis has been used successfully to identify the genes underlying rare mendelian disorders. It has also played a role in attempts to map genes for common non-mendelian (also known as 'complex' or 'multifactorial') diseases such as psychiatric disorders. However, despite extensive efforts progress has been slow, marred by inconsistent or ambiguous results. Uncertainties about the utility of the linkage approach for complex genetic traits has spurred interest in association studies with candidate genes, as an alternate strategy. Recently, with the advent of new molecular tools, in particular high-density, single-nucleotide polymorphisms (SNPs) maps, it has been argued that, while linkage analysis may retain some role, genome-wide association studies with SNPs offer a superior strategy for unraveling genetic complexity. In this paper I review these issues, stressing the pros and cons of the various strategies. I propose that: (1) the uncertainties in association studies may have been underestimated; (2) neither method is sufficient or optimal; and (3) a joint linkage and association approach, together with genomic, statistical and computational advances, may have greater promise for understanding the genetic underpinnings of complex disorders in the new millennium.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.