ArticleEndocrinology2001
Gonadotropin-releasing hormone receptor in the teleost Haplochromis burtoni: structure, location, and function.
Article in Endocrinology, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
13 citing papers in PubMed, 60 citations in OpenAlex.
- Specificity of polyclonal oligopeptide antisera targeting glycoprotein hormones from the Japanese Eel (Anguilla japonica).Biotechnology letters · 2026Article
- No evidence for sex chromosomes in natural populations of the cichlid fish Astatotilapia burtoni.G3 (Bethesda, Md.) · 2023Article
- Construction of High-Density Genetic Map and Mapping of Sex-Related Loci in the Yellow Catfish (Pelteobagrus fulvidraco).Marine biotechnology (New York, N.Y.) · 2020Article
- The puzzling phylogeography of the haplochromine cichlid fishEcology and evolution · 2018Article
- A Type IIb, but Not Type IIa, GnRH Receptor Mediates GnRH-Induced Release of Growth Hormone in the Ricefield Eel.Frontiers in endocrinology · 2018Article
- Social regulation of male reproductive plasticity in an African cichlid fish.Integrative and comparative biology · 2013Review
- Functional significance of GnRH and kisspeptin, and their cognate receptors in teleost reproduction.Frontiers in endocrinology · 2013Article
- Early development of the gonadotropin-releasing hormone neuronal network in transgenic zebrafish.Frontiers in endocrinology · 2013Article
- Reproductive status regulates expression of sex steroid and GnRH receptors in the olfactory bulb.Behavioural brain research · 2010Article
- Annotation of expressed sequence tags for the East African cichlid fish Astatotilapia burtoni and evolutionary analyses of cichlid ORFs.BMC genomics · 2008Article
- The gonadotropin-releasing hormone type I receptor is expressed in the mouse cerebellum.Cerebellum (London, England) · 2008Article
- GnRH and gpcr: laser-captured single cell gene profiling.Fish physiology and biochemistry · 2005Article
- Two visual processing pathways are targeted by gonadotropin-releasing hormone in the retina.Brain, behavior and evolution · 2005Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
Abstract
GnRH acts via GnRH receptors (GnRH-R) in the pituitary to cause the release of gonadotropins that regulate vertebrate reproduction. In the teleost fish, Haplochromis burtoni, reproduction is socially regulated through the hypothalamus-pituitary-gonadal axis, making the pituitary GnRH-R a likely site of action for this control. As a first step toward understanding the role of GnRH-R in the social control of reproduction, we cloned and sequenced candidate GnRH-R complementary DNAs from H. burtoni tissue. We isolated a complementary DNA that predicts a peptide encoding a G protein-coupled receptor that shows highest overall identity to other fish type I GnRH-R (goldfish IA and IB and African catfish). Functional testing of the expressed protein in vitro confirmed high affinity binding of multiple forms of GNRH: Localization of GnRH-R messenger RNA using RT-PCR revealed that it is widely distributed in the brain and retina as well as elsewhere in the body. Taken together, these data suggest that this H. burtoni GnRH receptor probably interacts in vivo with all three forms of GNRH:
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.