ArticleOncogene2001
Transcription factor ATF3 partially transforms chick embryo fibroblasts by promoting growth factor-independent proliferation.
Article in Oncogene, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
29 citing papers in PubMed, 64 citations in OpenAlex.
- Key role for Rac in the early transcriptional response to extracellular matrix stiffness and stiffness-dependent repression of ATF3.Journal of cell science · 2023Article
- Transcription Factor ATF3 Participates in DeltaNp63-Mediated Proliferation of Corneal Epithelial Cells.Journal of personalized medicine · 2023Article
- Neddylation inhibition activates the protective autophagy through NF-κB-catalase-ATF3 Axis in human esophageal cancer cells.Cell communication and signaling : CCS · 2020Article
- Relevance of HCN2-expressing human mesenchymal stem cells for the generation of biological pacemakers.Stem cell research & therapy · 2016Article
- Article
- Activating transcription factor 3 interferes with p21 activation in histone deacetylase inhibitor-induced growth inhibition of epidermoid carcinoma cells.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2015Article
- Nerve injury-induced c-Jun activation in Schwann cells is JNK independent.BioMed research international · 2014Article
- Identification of a c-Jun N-terminal kinase-2-dependent signal amplification cascade that regulates c-Myc levels in ras transformation.Oncogene · 2012Article
- Activating transcription factor 3 and the nervous system.Frontiers in molecular neuroscience · 2012Article
- Multiple transcription factor families regulate axon growth and regeneration.Developmental neurobiology · 2011Review
- ATF3, an HTLV-1 bZip factor binding protein, promotes proliferation of adult T-cell leukemia cells.Retrovirology · 2011Article
- Article
- Activating transcription factor 3 activates p53 by preventing E6-associated protein from binding to E6.The Journal of biological chemistry · 2010Article
- Whole genome expression analysis reveals differential effects of TiO2 nanotubes on vascular cells.Nano letters · 2010Article
- Differential usage of alternate promoters of the human stress response gene ATF3 in stress response and cancer cells.Nucleic acids research · 2009Article
- Article
- Gene expression profiles of endothelial progenitor cells by oligonucleotide microarray analysis.Molecular and cellular biochemistry · 2007Article
- The transcription factor ATF3 is upregulated during chondrocyte differentiation and represses cyclin D1 and A gene transcription.BMC molecular biology · 2006Article
- Oxidative stress-responsive transcription factor ATF3 potentially mediates diabetic angiopathy.Molecular and cellular biology · 2006Article
- Stress response gene ATF3 is a target of c-myc in serum-induced cell proliferation.The EMBO journal · 2005Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Activating Transcription Factor 3 (ATF3) is a member of the bZip family of transcription factors. Previous studies in mammalian cells suggested that like other bZip family members e.g. Jun and Fos, ATF3 might play a role in the control of cell proliferation and participate in oncogenic transformation. To investigate this putative ATF3 function directly, the rat ATF3 protein was compared with v-Jun for its ability to transform primary cultures of chick embryo fibroblasts (CEFs). Like CEFs accumulating v-Jun, CEFs accumulating the ATF3 protein displayed a typical, fusiform morphology, associated with an enhanced capacity to grow in medium with reduced amount of serum. However, in contrast to v-Jun-transformed CEFs, the ATF3 overexpressing cells could not promote colony formation from single cells in agar. Partial transformation induced by ATF3 was found to be associated with repression of multiple cellular genes that are also down-regulated by v-Jun, including those coding for the extracellular components fibronectin, decorin, thrombospondin 2, and the pro-apoptotic protein Par-4. These data demonstrate that, at least in primary avian cells, rat ATF3 possesses an intrinsic oncogenic potential. Moreover, the results suggest that ATF3 might induce growth factor independence by down-regulating a subset of the genes repressed by v-Jun.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.