ArticleOncogene2001
E2F-1 induces the stabilization of p53 but blocks p53-mediated transactivation.
Article in Oncogene, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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Who cites it
15 citing papers in PubMed, 36 citations in OpenAlex.
- TP53/mTORC1-mediated bidirectional regulation of PD-L1 modulates immune evasion in hepatocellular carcinoma.Journal for immunotherapy of cancer · 2023Article
- Transcription factors that interact with p53 and Mdm2.International journal of cancer · 2016Review
- Isg15 controls p53 stability and functions.Cell cycle (Georgetown, Tex.) · 2014Article
- ATM-dependent E2F1 accumulation in the nucleolus is an indicator of ribosomal stress in early response to DNA damage.Cell cycle (Georgetown, Tex.) · 2014Article
- A novel E2F-like protein involved in transcriptional activation of cyst wall protein genes in Giardia lamblia.The Journal of biological chemistry · 2011Article
- MEF/ELF4 transactivation by E2F1 is inhibited by p53.Nucleic acids research · 2011Article
- Cell cycle regulator E2F1 modulates angiogenesis via p53-dependent transcriptional control of VEGF.Proceedings of the National Academy of Sciences of the United States of America · 2006Article
- Review
- Regulation of epidermal apoptosis and DNA repair by E2F1 in response to ultraviolet B radiation.Oncogene · 2005Article
- E2F1 induces phosphorylation of p53 that is coincident with p53 accumulation and apoptosis.Molecular and cellular biology · 2002Article
- Loss of neurofibromatosis-1 and p19(ARF) cooperate to induce a multiple tumor phenotype.Oncogene · 2002Article
- Mdm2 inhibition of p53 induces E2F1 transactivation via p21.Oncogene · 2002Article
- Autoinhibitory regulation of p73 by Delta Np73 to modulate cell survival and death through a p73-specific target element within the Delta Np73 promoter.Molecular and cellular biology · 2002Article
- Novel function of the cyclin A binding site of E2F in regulating p53-induced apoptosis in response to DNA damage.Molecular and cellular biology · 2002Article
- Article
Corrections and comments
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Authors and funding
6 authors at 4 institutions in 1 country.
Funding
Abstract
E2F-1 induces p53 accumulation and E2F-1 and p53 form a physical complex, which affects the ability of E2F-1 to activate transcription. We mapped the domains on E2F-1 that interact with p53 and found two p53-binding domains. To understand the functional consequences of the E2F-1/p53 association on p53 activities we identified the domains of E2F-1 that were responsible for the accumulation of p53. Unexpectedly, we found that the E2F-1 transactivation domain was dispensable for p53 induction. By contrast, further deletion of the DP-1 interaction/'marked' box domain eliminated p53 accumulation. Radiolabeling pulse/chase analysis demonstrated that E2F-1 caused post-translational stabilization of p53. Although E2F-1 caused the stabilization of p53, E2F-1 expression impaired p53-dependent transactivation. Thus, the E2F-1 : p53 interaction may provide a checkpoint function to inactivate overactive E2F-1, but the association may also inactivate p53 transactivation to allow cell cycle progression.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.