ArticleOncogene2001
Functional evidence for a telomerase repressor gene on human chromosome 10p15.1.
Article in Oncogene, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 52 citations in OpenAlex.
- Review
- A pathway from chromosome transfer to engineering resulting in human and mouse artificial chromosomes for a variety of applications to bio-medical challenges.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2015Review
- Identification of PITX1 as a TERT suppressor gene located on human chromosome 5.Molecular and cellular biology · 2011Article
- Localization of an hTERT repressor region on human chromosome 3p21.3 using chromosome engineering.Genome integrity · 2010Article
- A noncoding RNA gene on chromosome 10p15.3 may function upstream of hTERT.BMC molecular biology · 2009Article
- Understanding and exploiting hTERT promoter regulation for diagnosis and treatment of human cancers.Cancer science · 2008Review
- A genome-wide map of aberrantly expressed chromosomal islands in colorectal cancer.Molecular cancer · 2006Article
- Hepatocellular carcinoma pathogenesis: from genes to environment.Nature reviews. Cancer · 2006Review
- The manipulation of chromosomes by mankind: the uses of microcell-mediated chromosome transfer.Chromosoma · 2005Review
- Function of AP-1 in transcription of the telomerase reverse transcriptase gene (TERT) in human and mouse cells.Molecular and cellular biology · 2005Article
- Identification of a </= 600-kb region on human chromosome 1q42.3 inducing cellular senescence.Oncogene · 2003Article
- Human telomerase and its regulation.Microbiology and molecular biology reviews : MMBR · 2002Review
- Down-regulation of GATA-3 expression during human papillomavirus-mediated immortalization and cervical carcinogenesis.The American journal of pathology · 2002Article
- Tiptoeing to chromosome tips: facts, promises and perils of today's human telomere biology.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2002Review
- Review
- hTR repressor-related gene on human chromosome 10p15.1.British journal of cancer · 2001Article
Corrections and comments
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Authors and funding
11 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Based on the sites of frequent allelic loss in hepatocellular carcinoma, five normal human chromosomes (2, 4, 5, 10 and 16) were transferred individually into a telomerase-positive human hepatocellular carcinoma cell line, Li7HM, by microcell-mediated chromosome transfer (MMCT). Chromosome 10, but not the others, repressed telomerase activity immediately and stopped cell growth after 50 population doublings (PDs). Loss of the transferred 10p loci resulted in the emergence of revertant cells that continued to proliferate and expressed telomerase activity, suggesting the presence of a telomerase repressor gene on this chromosomal arm. Transfer of a series of defined fragments from chromosome 10p successfully narrowed down the responsible region: a 28.9-cM region on 10p15 (between WI-4752 and D10S249), but not a 26.2-cM region (between D10S1728 and D10S249), caused repression of telomerase activity and progressive telomere shortening. A strong correlation between the expression level of telomerase catalytic subunit gene (hTERT) and telomerase activity was observed. These findings suggest that a novel telomerase repressor gene which controls the expression of hTERT is located on the 2.7-cM region (between WI-4752 and D10S1728) on chromosome 10p15.1.
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