ArticleOncogene2001
Mechanisms of regulation of cell adhesion and motility by insulin receptor substrate-1 in prostate cancer cells.
Article in Oncogene, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
22 citing papers in PubMed, 69 citations in OpenAlex.
- The inhibitory effects of COL1A2 on colorectal cancer cell proliferation, migration, and invasion.Journal of Cancer · 2018Article
- Calreticulin affects cell adhesiveness through differential phosphorylation of insulin receptor substrate-1.Cellular & molecular biology letters · 2014Article
- Insulin-like growth factor 1 receptor is a prognostic factor in classical Hodgkin lymphoma.PloS one · 2014Article
- Molecular profiling of prostatic acinar morphogenesis identifies PDCD4 and KLF6 as tissue architecture-specific prognostic markers in prostate cancer.The American journal of pathology · 2013Article
- Insulin receptor substrate 1 expression enhances the sensitivity of 32D cells to chemotherapy-induced cell death.Experimental cell research · 2012Article
- Nuclear IRS-1 and cancer.Journal of cellular physiology · 2012Review
- Depletion of insulin receptor substrate 2 reverses oncogenic transformation induced by v-src.Acta pharmacologica Sinica · 2011Article
- Estrogen receptor beta-mediated nuclear interaction between IRS-1 and Rad51 inhibits homologous recombination directed DNA repair in medulloblastoma.Journal of cellular physiology · 2009Article
- IGF-IR in neuroprotection and brain tumors.Frontiers in bioscience (Landmark edition) · 2009Review
- Transgenic overexpression of insulin receptor substrate 1 in hepatocytes enhances hepatocellular proliferation in young mice only.Hepatology research : the official journal of the Japan Society of Hepatology · 2008Article
- Nuclear insulin receptor substrate-1 activates promoters of cell cycle progression genes.Oncogene · 2008Article
- Interaction between serine phosphorylated IRS-1 and beta1-integrin affects the stability of neuronal processes.Journal of neuroscience research · 2007Article
- Insulin receptor substrates mediate distinct biological responses to insulin-like growth factor receptor activation in breast cancer cells.British journal of cancer · 2006Article
- Turnover of the active fraction of IRS1 involves raptor-mTOR- and S6K1-dependent serine phosphorylation in cell culture models of tuberous sclerosis.Molecular and cellular biology · 2006Article
- Transformation by the simian virus 40 T antigen is regulated by IGF-I receptor and IRS-1 signaling.Oncogene · 2006Article
- Expression of insulin receptor substrate 1 in primary breast cancer and lymph node metastases.Journal of clinical pathology · 2005Article
- Selective modulation of type 1 insulin-like growth factor receptor signaling and functions by beta1 integrins.The Journal of cell biology · 2004Article
- IGF-I receptor, cell-cell adhesion, tumour development and progression.Journal of molecular histology · 2004Review
- Role of the insulin-like growth factor I/insulin receptor substrate 1 axis in Rad51 trafficking and DNA repair by homologous recombination.Molecular and cellular biology · 2003Article
- Growth factor receptors as therapeutic targets: strategies to inhibit the insulin-like growth factor I receptor.Oncogene · 2003Review
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
LNCaP cells are human prostatic cancer cells that have a frame-shift mutation of the tumor suppressor gene PTEN and do not express the insulin receptor substrate-1 (IRS-1), a major substrate of the type 1 insulin-like growth factor receptor (IGF-IR). Ectopic expression of IRS-1 in LNCaP cells increases cell adhesion and decreases cell motility by an IGF-I-independent mechanism. We show now that these effects of IRS-1 are accompanied by serine phosphorylation of IRS-1 and are inhibited by inhibitors of phosphatidylinositol 3-kinase (PI3K). We have confirmed the requirement for PI3K activity and serine phosphorylation by the use of IRS-1 mutants, expressed in LNCaP cells. Serine phosphorylation inhibits IGF-I-induced tyrosyl phosphorylation of IRS-1, which is restored by the expression of wild-type PTEN or by inhibition of PI3K activity. Finally, IRS-1 in LNCaP cells co-immunoprecipitates with integrin alpha 5 beta 1, and the association is again IGF-I-independent. We conclude that in LNCaP cells, IRS-1 is serine phosphorylated by PI3K, generating effects that are different, and even opposite, from those generated by IGF-I.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.