ArticleOncogene2001
Cytokine response gene 8 (CR8) regulates the cell cycle G1-S phase transition and promotes cellular survival.
Article in Oncogene, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
4 citing papers in PubMed, 7 citations in OpenAlex.
- SUMO modification of Stra13 is required for repression of cyclin D1 expression and cellular growth arrest.PloS one · 2012Article
- Stra13 regulates satellite cell activation by antagonizing Notch signaling.The Journal of cell biology · 2007Article
- bHLH-Orange Transcription Factors in Development and Cancer.Translational oncogenomics · 2007Article
- The FHA domain protein SNIP1 is a regulator of the cell cycle and cyclin D1 expression.Oncogene · 2004Article
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Cellular proliferation and survival are modulated by the expression of specific genes. Cytokine response gene 8 (CR8), which was originally cloned as an IL-2-induced gene in human T lymphocytes, encodes a basic helix--loop--helix (bHLH) transcription factor. The CR8 gene product is highly conserved among human, mouse and rat, and contains sequence motifs that distinguish it from other bHLH families. The CR8 gene is ubiquitously expressed, and CR8 gene expression is induced by both growth-promoting as well as growth-inhibitory stimuli. As bHLH proteins have been found to regulate both the G1-S phase cell cycle transition, as well as cellular survival, the effects of CR8 on these processes were investigated. Ectopic CR8 expression in asynchronous U2OS cell cultures reduces the percentage of cells in the cell cycle S phase, and also slows the entry of G1-synchronized cells into S phase. The prolonged G1 interval correlates with impaired elevation of cyclin E protein and prolonged p21 protein expression in G1. CR8 expression also protects U2OS cells from serum-withdrawal induced apoptosis. These results indicate that CR8 is an important modulator of both the G1-S phase cell cycle transition, and cellular survival.
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Registered trials
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