ReviewOncogene2001
In vivo functions of heterotrimeric G-proteins: studies in Galpha-deficient mice.
Review in Oncogene, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
32 citing papers in PubMed, 85 citations in OpenAlex.
- G protein selectivity profile of GPR56/ADGRG1 and its effect on downstream effectors.Research square · 2024Article
- G protein selectivity profile of GPR56/ADGRG1 and its effect on downstream effectors.Cellular and molecular life sciences : CMLS · 2024Article
- GPCR-Gα13 Involvement in Mitochondrial Function, Oxidative Stress, and Prostate Cancer.International journal of molecular sciences · 2024Review
- Structure-based identification of a G protein-biased allosteric modulator of cannabinoid receptor CB1.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Article
- Review
- Gα-13 induces CThe Journal of biological chemistry · 2019Article
- The Ric-8A/Gα13/FAK signalling cascade controls focal adhesion formation during neural crest cell migration inDevelopment (Cambridge, England) · 2018Article
- Platelet Signaling and Disease: Targeted Therapy for Thrombosis and Other Related Diseases.Pharmacological reviews · 2018Review
- Gα12 regulates osteoclastogenesis by modulating NFATc1 expression.Journal of cellular and molecular medicine · 2018Article
- Synergistic Signaling by Light and Acetylcholine in Mouse Iris Sphincter Muscle.Current biology : CB · 2017Article
- G-protein genomic association with normal variation in gray matter density.Human brain mapping · 2015Article
- Molecular approaches for manipulating astrocytic signaling in vivo.Frontiers in cellular neuroscience · 2015Review
- Harnessing the platelet signaling network to produce an optimal hemostatic response.Hematology/oncology clinics of North America · 2013Review
- S1pr2/Gα13 signaling controls myocardial migration by regulating endoderm convergence.Development (Cambridge, England) · 2013Article
- Inactivation of Pde8b enhances memory, motor performance, and protects against age-induced motor coordination decay.Genes, brain, and behavior · 2012Article
- Platelet signaling.Handbook of experimental pharmacology · 2012Review
- Signalling mechanisms of RhoGTPase regulation by the heterotrimeric G proteins G12 and G13.Journal of biochemistry · 2011Review
- G12 signaling through c-Jun NH2-terminal kinase promotes breast cancer cell invasion.PloS one · 2011Article
- Adenosine A2A receptor signaling and golf assembly show a specific requirement for the gamma7 subtype in the striatum.The Journal of biological chemistry · 2010Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Heterotrimeric guanine nucleotide binding proteins (G-proteins) mediate the effects of numerous hormones, neurotransmitters or sensory stimuli by coupling their transmembranous receptors to various effectors like enzymes and ion channels. Changes in the activity of these effector molecules eventually lead to the regulation of multiple cellular functions ranging from short term regulatory processes like the control of secretion rates, muscle tonus or metabolic processes to long term effects like regulation of growth and differentiation. Heterotrimeric G-proteins play a pivotal role in this transmembrane signaling process as they take part in processing and sorting of incoming signals as well as in adjusting the sensitivity of the system. This review describes some of the new insights into the biological role of G-protein mediated signaling processes provided by the analysis of mice genetically engineered to lack distinct G-protein alpha-subunits.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.