ArticleOncogene2001
Expression analysis using DNA microarrays demonstrates that E2F-1 up-regulates expression of DNA replication genes including replication protein A2.
Article in Oncogene, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
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Who cites it
28 citing papers in PubMed, 73 citations in OpenAlex.
- scGREAT: Transformer-based deep-language model for gene regulatory network inference from single-cell transcriptomics.iScience · 2024Article
- A novel E2F1-regulated lncRNA, LAPAS1, is required for S phase progression and cell proliferation.Oncotarget · 2021Article
- A novel mitosis-associated lncRNA, MA-linc1, is required for cell cycle progression and sensitizes cancer cells to Paclitaxel.Oncotarget · 2015Article
- Transcriptional control of stem cell fate by E2Fs and pocket proteins.Frontiers in genetics · 2015Review
- YB-1, the E2F pathway, and regulation of tumor cell growth.Journal of the National Cancer Institute · 2012Article
- Genomics Portals: integrative web-platform for mining genomics data.BMC genomics · 2010Article
- Oncogenic pathway combinations predict clinical prognosis in gastric cancer.PLoS genetics · 2009Article
- Influence of fatty acid diets on gene expression in rat mammary epithelial cells.Physiological genomics · 2009Article
- Prohibitin physically interacts with MCM proteins and inhibits mammalian DNA replication.Cell cycle (Georgetown, Tex.) · 2009Article
- Differential gene expression profiling in human cholangiocarcinoma cells treated with Clonorchis sinensis excretory-secretory products.Parasitology research · 2009Article
- [Not Available].Journal of oncology · 2009Article
- Regulatory subunits of PKA define an axis of cellular proliferation/differentiation in ovarian cancer cells.BMC medical genomics · 2008Article
- Individual retinal progenitor cells display extensive heterogeneity of gene expression.PloS one · 2008Article
- Expression of thymidylate synthase in human cells is an early G(1) event regulated by CDK4 and p16INK4A but not E2F.British journal of cancer · 2007Article
- Muscle-specific microRNA miR-206 promotes muscle differentiation.The Journal of cell biology · 2006Article
- Tissue-specific tumor suppressor activity of retinoblastoma gene homologs p107 and p130.Genes & development · 2004Article
- Expression of MCM10 and TopBP1 is regulated by cell proliferation and UV irradiation via the E2F transcription factor.Oncogene · 2004Article
- Article
- Apoptosis associated with deregulated E2F activity is dependent on E2F1 and Atm/Nbs1/Chk2.Molecular and cellular biology · 2004Article
- Genome-wide analysis of gene expression regulated by the HAT cofactor Trrap in conditional knockout cells.Nucleic acids research · 2003Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The transcription factor E2F-1 plays a pivotal role in the regulation of G1/S transition in higher eukaryotes cell cycle. We used a cell line containing an inducible E2F-1 and oligonucleotide microarray analysis to identify novel E2F target genes. We show that E2F-1 up-regulates the expression of a number of genes coding for components of the DNA replication machinery. Among them is the gene coding for the 32 Kd subunit of replication protein A (RPA2). Replication protein A is the most abundant single strand DNA binding complex and it is essential for DNA replication. We demonstrate that RPA2 is a novel E2F target gene whose expression can be directly regulated by E2F-1 via E2F binding sites in its promoter. In addition, expression of Topoisomerase IIalpha and subunit IV of DNA polymerase alpha is also up-regulated upon E2F-1 induction. Taken together, these results provide novel links between components of the DNA replication machinery and the cell growth regulatory pathway involving the Rb tumor suppressor and E2F.
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