ArticleOncogene2001
Differential expression and regulation of the retinoblastoma family of proteins during testicular development and spermatogenesis: roles in the control of germ cell proliferation, differentiation and apoptosis.
Article in Oncogene, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
15 citing papers in PubMed, 41 citations in OpenAlex.
- A Descriptive Study of Brown Bear (Animals : an open access journal from MDPI · 2025Article
- CEP128 is involved in spermatogenesis in humans and mice.Nature communications · 2022Article
- Retinoblastoma-E2F Transcription Factor Interplay Is Essential for Testicular Development and Male Fertility.Frontiers in endocrinology · 2022Review
- Diverse roles for CDK-associated activity during spermatogenesis.FEBS letters · 2019Review
- Hyper sensitive protein detection by Tandem-HTRF reveals Cyclin D1 dynamics in adult mouse.Scientific reports · 2015Article
- Retinoblastoma protein (RB) interacts with E2F3 to control terminal differentiation of Sertoli cells.Cell death & disease · 2014Article
- Retinoblastoma protein (RB1) controls fate determination in stem cells and progenitors of the mouse male germline.Biology of reproduction · 2013Article
- Gonocyte development in rats: proliferation, distribution and death revisited.Histochemistry and cell biology · 2012Article
- Asynchronous expression of the homeodomain protein CUX1 in Sertoli cells and spermatids during spermatogenesis in mice.Biology of reproduction · 2011Article
- Effect of high intratesticular estrogen on global gene expression and testicular cell number in rats.Reproductive biology and endocrinology : RB&E · 2010Article
- Retinoblastoma protein plays multiple essential roles in the terminal differentiation of Sertoli cells.Molecular endocrinology (Baltimore, Md.) · 2009Article
- Cell cycle analysis of fetal germ cells during sex differentiation in mice.Biology of the cell · 2009Article
- GFP reporter mice for the retinoblastoma-related cell cycle regulator p107.Cell cycle (Georgetown, Tex.) · 2008Article
- Differential expression of members of the E2F family of transcription factors in rodent testes.Reproductive biology and endocrinology : RB&E · 2006Article
- Previously uncharacterized roles of platelet-activating factor acetylhydrolase 1b complex in mouse spermatogenesis.Proceedings of the National Academy of Sciences of the United States of America · 2003Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Normal spermatogenesis is highly dependent on well-balanced germ cell proliferation, differentiation, and apoptosis. However, the molecular mechanisms that govern these processes are largely unknown. Retinoblastoma family proteins (pRb, p107 and p130) are potentially important regulators of cell growth, differentiation and apoptosis. pRb has been shown to be expressed in the rat testis and involved in the regulation of spermatogenesis. In the present study, the expression and localization of the other two pRb family members, p107 and p130, were analysed at both mRNA and protein levels during testicular development and spermatogenesis using Northern, Western blotting, immunohistochemistry, and in situ hybridization. Furthermore, changes of levels and phosphorylation status of pRb family proteins in response to growth suppression and/or apoptosis induction were investigated using a seminiferous tubule culture system and three animal models. Our data suggest that: (1) pRb family proteins are differentially expressed in the rat testis and they function in a cell-type-specific manner during testicular development and spermatogenesis; (2) they participate in the control of germ cell cycle and act in a cell cycle-phase-specific fashion during germ cell proliferation, and (3) they are also involved in the regulation of apoptosis of germ cells and Leydig cells.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.