ArticleOncogene2001
Alternative splicing of the imprinted candidate tumor suppressor gene ZAC regulates its antiproliferative and DNA binding activities.
Article in Oncogene, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 48 citations in OpenAlex.
- Plagl1 regulates the retinal progenitor cell to Müller glial cell transition.PLoS genetics · 2026Article
- Genomic Imprinting at the PorcineGenes · 2021Article
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- Chromosome 6q24-related diabetes mellitus.Clinical pediatric endocrinology : case reports and clinical investigations : official journal of the Japanese Society for Pediatric Endocrinology · 2018Article
- A tissue-specific promoter derived from a SINE retrotransposon drives biallelic expression of PLAGL1 in human lymphocytes.PloS one · 2017Article
- Imprinted Zac1 in neural stem cells.World journal of stem cells · 2015Review
- A systems-level approach to parental genomic imprinting: the imprinted gene network includes extracellular matrix genes and regulates cell cycle exit and differentiation.Genome research · 2015Article
- Zac1 regulates cell cycle arrest in neuronal progenitors via Tcf4.Molecular and cellular biology · 2014Article
- A novel variation of PLAGL1 in Chinese patients with isolated ventricular septal defect.Genetic testing and molecular biomarkers · 2012Article
- Transient neonatal diabetes mellitus gene Zac1 impairs insulin secretion in mice through Rasgrf1.Molecular and cellular biology · 2012Article
- Specific changes in the expression of imprinted genes in prostate cancer--implications for cancer progression and epigenetic regulation.Asian journal of andrology · 2012Review
- Resolution of infection promotes a state of dormancy and long survival of CD4 memory T cells.Immunology and cell biology · 2011Article
- Zac1 plays a key role in the development of specific neuronal subsets in the mouse cerebellum.Neural development · 2011Article
- Differential expression pattern of ZAC in developing mouse and human pancreas.Journal of molecular histology · 2011Article
- Regulation of cardiomyocyte Glut4 expression by ZAC1.The Journal of biological chemistry · 2010Article
- Demonstration of all-or-none loss of imprinting in mRNA expression in single cells.Nucleic acids research · 2009Article
- Lot1 is a key element of the pituitary adenylate cyclase-activating polypeptide (PACAP)/cyclic AMP pathway that negatively regulates neuronal precursor proliferation.The Journal of biological chemistry · 2009Article
- A new coactivator function for Zac1's C2H2 zinc finger DNA-binding domain in selectively controlling PCAF activity.Molecular and cellular biology · 2008Article
- Neonatal diabetes mellitus.Endocrine reviews · 2008Review
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
ZAC encodes a zinc finger protein with antiproliferative activity, is maternally imprinted and is a candidate for the tumor suppressor gene on 6q24. ZAC expression is frequently lost in breast and ovary tumor-derived cell lines and down-regulated in breast primary tumors. In this report, we describe ZACDelta2, an alternatively spliced variant of ZAC lacking the sequence encoding the two N-terminal zinc fingers. Messenger RNAs encoding ZAC or ZACDelta2 were equally abundant and both proteins were nuclear. ZACDelta2 displayed an improved transactivation activity and an enhanced affinity for a ZAC binding site, suggesting that the two N-terminal zinc fingers negatively regulated ZAC binding to its target DNA sequences. Both proteins were equally efficient in preventing colony formation, indicating similar overall antiproliferative activities. However, these activities resulted from a differential regulation of apoptosis vs cell cycle progression since ZACDelta2 was more efficient at induction of cell cycle arrest than ZAC, whereas it was the reverse for apoptosis induction. Hence, these data further underline that ZAC gene is critically controlled, both at the transcriptional level through imprinting and at the functional level through alternative splicing.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.