ArticleMolecular and cellular biology2001
BSF binds specifically to the bicoid mRNA 3' untranslated region and contributes to stabilization of bicoid mRNA.
Article in Molecular and cellular biology, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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Who cites it
37 citing papers in PubMed, 65 citations in OpenAlex.
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- A novel evolutionary conserved mechanism of RNA stability regulates synexpression of primordial germ cell-specific genes prior to the sex-determination stage in medaka.PLoS biology · 2019Article
- Unraveling Novel Mechanisms of Neurodegeneration Through a Large-Scale Forward Genetic Screen inFrontiers in genetics · 2018Review
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- The mRNA-bound proteome of the early fly embryo.Genome research · 2016Article
- A Mismatch EndoNuclease Array-Based Methodology (MENA) for Identifying Known SNPs or Novel Point Mutations.Microarrays (Basel, Switzerland) · 2016Article
- RNA sequences required for the noncoding function of oskar RNA also mediate regulation of Oskar protein expression by Bicoid Stability Factor.Developmental biology · 2015Article
- Impaired Mitochondrial Energy Production Causes Light-Induced Photoreceptor Degeneration Independent of Oxidative Stress.PLoS biology · 2015Article
- RNAi silencing of the SoxE gene suppresses cell proliferation in silkworm BmN4 cells.Molecular biology reports · 2014Article
- The leucine-rich pentatricopeptide repeat-containing protein (LRPPRC) does not activate transcription in mammalian mitochondria.The Journal of biological chemistry · 2013Article
- Muscleblind, BSF and TBPH are mislocalized in the muscle sarcomere of a Drosophila myotonic dystrophy model.Disease models & mechanisms · 2013Article
- Transcriptional analysis of the Arabidopsis ovule by massively parallel signature sequencing.Journal of experimental botany · 2012Article
- Molecular evolution of pentatricopeptide repeat genes reveals truncation in species lacking an editing target and structural domains under distinct selective pressures.BMC evolutionary biology · 2012Article
- Genome-wide analysis of GLD-1-mediated mRNA regulation suggests a role in mRNA storage.PLoS genetics · 2012Article
- New insights into the regulation of RNP granule assembly in oocytes.International review of cell and molecular biology · 2012Review
- The bicoid stability factor controls polyadenylation and expression of specific mitochondrial mRNAs in Drosophila melanogaster.PLoS genetics · 2011Article
- Article
- Dynamic organization and plasticity of sponge bodies.Developmental dynamics : an official publication of the American Association of Anatomists · 2009Article
- Systematic functional analysis of Bicaudal-D serine phosphorylation and intragenic suppression of a female sterile allele of BicD.PloS one · 2009Article
- The pentatricopeptide repeat protein PPR5 stabilizes a specific tRNA precursor in maize chloroplasts.Molecular and cellular biology · 2008Article
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
The early stages of Drosophila melanogaster development rely extensively on posttranscriptional forms of gene regulation. Deployment of the anterior body patterning morphogen, the Bicoid protein, requires both localization and translational regulation of the maternal bicoid mRNA. Here we provide evidence that the bicoid mRNA is also selectively stabilized during oogenesis. We identify and isolate a protein, BSF, that binds specifically to IV/V RNA, a minimal form of the bicoid mRNA 3' untranslated region that supports a normal program of mRNA localization during oogenesis. Mutations that disrupt the BSF binding site in IV/V RNA or substantially reduce the level of BSF protein lead to reduction in IV/V RNA levels, indicating a role for BSF in RNA stabilization. The BSF protein is novel and lacks all of the characterized RNA binding motifs. However, BSF does include multiple copies of the PPR motif, whose function is unknown but appears in other proteins with roles in RNA metabolism.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.