Trial reportThorax2001
Increased expression of inducible nitric oxide synthase and cyclo-oxygenase-2 in the airway epithelium of asthmatic subjects and regulation by corticosteroid treatment.
Trial report in Thorax, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01239199 (Is the Exhaled Nitric Oxide in Infants a Predictive Marker of Asthma?), which is not on this map. Cited by 41 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Is the Exhaled Nitric Oxide in Infants a Predictive Marker of Asthma?
Who cites it
41 citing papers in PubMed, 154 citations in OpenAlex.
- Imaging pulmonary inducible nitric oxide synthase expression with PET.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2015Trial
- L-arginine reverses cigarette-induced reduction of fractional exhaled nitric oxide in asthmatic smokers.Inflammopharmacology · 2010Trial
- Article
- Differential expression of eicosanoid pathways after whole blood stimulation in asthma patients.The World Allergy Organization journal · 2025Article
- Dual therapy with corticosteroid ablates the beneficial effect of DP2 antagonism in chronic experimental asthma.Nature communications · 2024Article
- Membrane lipid composition of bronchial epithelial cells influences antiviral responses during rhinovirus infection.Tissue barriers · 2024Article
- Synergistic Pulmonoprotective Effect of Natural Prolyl Oligopeptidase Inhibitors in In Vitro and In Vivo Models of Acute Respiratory Distress Syndrome.International journal of molecular sciences · 2023Article
- Inner Shell of the Chestnut (Nutrients · 2022Article
- Overview of positron emission tomography in functional imaging of the lungs for diffuse lung diseases.The British journal of radiology · 2022Review
- ACO (Asthma-COPD Overlap) Is Independent from COPD, a Case in Favor: A Systematic Review.Diagnostics (Basel, Switzerland) · 2021Review
- Dysfunction of the hypothalamic-pituitary-adrenal axis in critical illness: a narrative review for emergency physicians.European journal of emergency medicine : official journal of the European Society for Emergency Medicine · 2020Review
- Comorbidity of Neurally Mediated Syncope and Allergic Disease in Children.Frontiers in immunology · 2020Review
- Prostaglandins in asthma and allergic diseases.Pharmacology & therapeutics · 2019Review
- Alkaloids fromMolecules (Basel, Switzerland) · 2018Article
- PET imaging approaches for inflammatory lung diseases: Current concepts and future directions.European journal of radiology · 2017Review
- Anti-Inflammatory Effect of Rosa rugosa Flower Extract in Lipopolysaccharide-Stimulated RAW264.7 Macrophages.Biomolecules & therapeutics · 2016Article
- Relative Adrenal Insufficiency in Pediatric Septic Shock.Journal of pediatric intensive care · 2015Review
- Human airway smooth muscle cells secrete amphiregulin via bradykinin/COX-2/PGE2, inducing COX-2, CXCL8, and VEGF expression in airway epithelial cells.American journal of physiology. Lung cellular and molecular physiology · 2015Article
- The role of prostaglandins in allergic lung inflammation and asthma.Expert review of respiratory medicine · 2015Review
- Impact of oxidative/nitrosative stress and inflammation on cognitive functions in patients with recurrent depressive disorders.Medical science monitor : international medical journal of experimental and clinical research · 2014Article
Corrections and comments
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundNitric oxide (NO) and prostanoids are mediators of vascular and bronchial tone that are postulated to be involved in asthma. Increased levels of both are found in asthmatic subjects and are synthesised by enzymes that have cytokine inducible forms: inducible NO synthase (iNOS) and cyclo-oxygenase-2 (COX-2), respectively. We hypothesised that the in vivo expression of iNOS and COX-2 in the airways would be increased in asthma, and that these cytokine inducible enzymes may represent targets for regulation by corticosteroid treatment.
methodsBronchial biopsy specimens were obtained from three groups of subjects: atopic asthmatics treated with beta(2) agonists alone (n=7), atopic asthmatics additionally receiving regular treatment with corticosteroids (n=8), and non-asthmatic control subjects (n=10). Expression of iNOS and COX-2 mRNA and immunoreactive protein was studied using in situ hybridisation and quantitative immunohistochemistry.
resultsImmunoreactivity and the hybridisation signal for iNOS and COX-2 were mainly localised in the airway epithelium. The proportion of epithelium immunostained was significantly greater in the non-steroid treated asthmatic subjects (iNOS 8.6 (1.8)%; COX-2 26.3 (4.6)%) than either the steroid treated asthmatics (iNOS 3.4 (1.0)%, p=0.009; COX-2 13.0 (0.6)%, p=0.0015) or the non-asthmatic controls (iNOS 4.2 (0.9)%, p=0.018; COX-2 11.6 (0.6)%, p=0.0003). Similarly, the hybridisation signal was stronger in the non-steroid treated group of asthmatic subjects than in the other two groups.
conclusionsThese findings highlight the potential role of the airway epithelium both as a contributor to the inflammatory process in asthma and as a target for inhaled corticosteroid treatment in this disease.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.